Korean J Fam Pract. 2017; 7(3): 348-352  https://doi.org/10.21215/kjfp.2017.7.3.348
Factors Affecting Mammographic Density in Korea Women Older Than 40 Years
Yeon-Hui Lee1, Min-Kyu Han1,*, Woo-Sung Lee1, Jin-Woo Park2
1Department of Family Medicine, Daerim Saint Mary’s Hospital, Seoul; 2Department of Family Medicine, Daesung Medical Center, Bucheon, Korea
Min-Kyu Han
Tel: +82-2-829-8350, Fax: +82-2-829-9320
E-mail: ilovebeeth@gmail.com
Received: March 10, 2016; Revised: September 9, 2016; Accepted: September 17, 2016; Published online: June 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: A dense mammogram is a risk factor of breast cancer and is associated with decreased mammographic sensitivity and specificity. The purpose of this study was to evaluate several factors that influence mammographic density in Korean women. Furthermore, we considered the effectiveness of mammography as a screening method for breast cancer.
Methods: The study subjects were 3,013 women older than 40 years who underwent screening mammography between January 2, 2015, and October 31, 2015, at health promotion centers. We classified breast density patterns as either non-dense or dense by using the Breast Imaging Reporting and Data System (BI-RADS). Univariate and multivariate logistic regression models were used for the statistical analysis.
Results: In the univariate logistic regression, older age, higher body mass index, older age at menarche, and history of lactation were associated with more-fatty breasts. On the contrary, premenopausal status and use of hormone replacement therapy were associated with dense breasts. In the multivariate logistic regression, age and body mass index were inversely associated with breast density. Compared with the postmenopausal women, the premenopausal women had a 2.66-fold increase in breast density (odds ratio, 2.66; 95% confidence interval, 1.93–3.67).
Conclusion: Young age, lower body mass index, and premenopausal status were significantly associated with dense breasts in the Korean women in this study who were older than 40 years. Therefore, women with dense breasts who have the aforementioned risk factors need to be managed by individualized strategies with consideration of their age, breast obesity, and so on.
Keywords: Breast; Mammography; Mammographic Density; Women
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