Korean J Fam Pract. 2017; 7(3): 377-381  https://doi.org/10.21215/kjfp.2017.7.3.377
Correlation between Reflux Esophagitis and Risk Factors
Jung-Sun Lee, Joo-Won Kang, Gang-Min Bae*
Department of Family Medicine, Namwon Medical Center, Namwon, Korea
Gang-Min Bae
Tel: +82-63-620-1179
E-mail: drgmbae@medigate.net
Received: February 22, 2016; Revised: June 14, 2016; Accepted: July 7, 2016; Published online: June 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Many studies have reported on the risk factors of gastroesophageal reflux disease (GERD), but the results are controversial and insufficient. Therefore, we investigated the correlation between the development of GERD and its potential risk factors.
Methods: Among the subjects who visited a health promotion center of a general hospital in Namwon between January and December 2014, 4,709 subjects who underwent esophagogastroendosopy and responded to a self-reported questionnaire about medical history, smoking habit, alcohol consumption, and low-density lipoprotein level were enrolled. Then, we investigated the prevalence of reflux esophagitis and the correlation between reflux esophagitis and its potential risk factors.
Results: The mean age of the 4,709 subjects was 57.0±10.7 years. Of the subjects, 660 subjects (14.0%) were classified as having reflux esophagitis and 4,049 subjects (86.0%) were classified as having non-reflux esophagitis. According to the results of the regression analysis for reflux esophagitis and its risk factors, current smokers (odds ratio [OR], 1.581; P<0.05), those with obesity according to BMI (OR, 1.586; P<0.05), men (OR, 1.575; P<0.05), those with obesity according to waist circumference (OR, 1.401; P<0.05), and alcohol drinkers (OR, 1.268; P<0.05) were likely to belong to the reflux esophagitis group.
Conclusion: In this study, current smoking, obesity (according to BMI and waist circumference), male sex, and alcohol drinking were related with the development of reflux esophagitis. The prevalence of reflux esophagitis is increasing in Korea, causing more concern and warranting further study.
Keywords: Reflux Esophagitis; Smoking; Alcohol; Obesity
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