Korean J Fam Pract. 2017; 7(3): 377-381  https://doi.org/10.21215/kjfp.2017.7.3.377
Correlation between Reflux Esophagitis and Risk Factors
Jung-Sun Lee, Joo-Won Kang, Gang-Min Bae*
Department of Family Medicine, Namwon Medical Center, Namwon, Korea
Gang-Min Bae
Tel: +82-63-620-1179
E-mail: drgmbae@medigate.net
Received: February 22, 2016; Revised: June 14, 2016; Accepted: July 7, 2016; Published online: June 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Many studies have reported on the risk factors of gastroesophageal reflux disease (GERD), but the results are controversial and insufficient. Therefore, we investigated the correlation between the development of GERD and its potential risk factors.
Methods: Among the subjects who visited a health promotion center of a general hospital in Namwon between January and December 2014, 4,709 subjects who underwent esophagogastroendosopy and responded to a self-reported questionnaire about medical history, smoking habit, alcohol consumption, and low-density lipoprotein level were enrolled. Then, we investigated the prevalence of reflux esophagitis and the correlation between reflux esophagitis and its potential risk factors.
Results: The mean age of the 4,709 subjects was 57.0±10.7 years. Of the subjects, 660 subjects (14.0%) were classified as having reflux esophagitis and 4,049 subjects (86.0%) were classified as having non-reflux esophagitis. According to the results of the regression analysis for reflux esophagitis and its risk factors, current smokers (odds ratio [OR], 1.581; P<0.05), those with obesity according to BMI (OR, 1.586; P<0.05), men (OR, 1.575; P<0.05), those with obesity according to waist circumference (OR, 1.401; P<0.05), and alcohol drinkers (OR, 1.268; P<0.05) were likely to belong to the reflux esophagitis group.
Conclusion: In this study, current smoking, obesity (according to BMI and waist circumference), male sex, and alcohol drinking were related with the development of reflux esophagitis. The prevalence of reflux esophagitis is increasing in Korea, causing more concern and warranting further study.
Keywords: Reflux Esophagitis; Smoking; Alcohol; Obesity
  1. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101: 1900-20.
    Pubmed CrossRef
  2. Kim DH, Suh YS. Smoking as a disease. Korean J Fam Med 2009; 30: 494502.
  3. Loffeld RJ, van der Putten AB. Rising incidence of reflux oesophagitis in patients undergoing upper gastrointestinal endoscopy. Digestion 2003; 68:141-4.
    Pubmed CrossRef
  4. Kang HS, Nam SW, Lee SE, Kwon HC, Park SM, Yang SU, et al. The prevalence of gastroesophageal reflux disease associated with age and body mass index in healthy Koreans. J Korean Geriatr Soc 2008; 12: 201-6.
  5. Yang SY, Lee OY, Bak YT, Jun DW, Lee SP, Lee SH, et al. Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea:a population-based study. Dig Dis Sci 2008; 53: 188-93.
    Pubmed CrossRef
  6. Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. Am J Gastroenterol 2005; 100: 747-53.
    Pubmed CrossRef
  7. Johnson LF. 24-hour pH monitoring in the study of gastroesophageal reflux. J Clin Gastroenterol 1980; 2: 387-99.
    Pubmed CrossRef
  8. Nandurkar S, Locke GR 3rd, Fett S, Zinsmeister AR, Cameron AJ, Talley NJ. Relationship between body mass index, diet, exercise and gastro-oesophageal reflux symptoms in a community. Aliment Pharmacol Ther 2004; 20:497-505.
    Pubmed CrossRef
  9. Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA Jr. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 2006; 354: 2340-8.
    Pubmed KoreaMed CrossRef
  10. Lee HL, Eun CS, Lee OY, Jeon YC, Sohn JH, Han DS, et al. Association between GERD-related erosive esophagitis and obesity. J Clin Gastroenterol 2008; 42: 672-5.
    Pubmed CrossRef
  11. Ministry of Health and Welfare. National alcohol policy: Blue Bird Plan 2020. Seoul: Ministry of Health and Welfare; 2011.
  12. Cai N, Ji GZ, Fan ZN, Wu YF, Zhang FM, Zhao ZF, et al. Association between body mass index and erosive esophagitis: a meta-analysis. World J Gastroenterol 2012; 18: 2545-53.
    Pubmed KoreaMed CrossRef
  13. Kim N, Lee SW, Cho SI, Park CG, Yang CH, Kim HS, et al. The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea. Aliment Pharmacol Ther 2008; 27: 173-85.
    Pubmed CrossRef
  14. Lee JY, Hong WK, Sohn KM, Kim DY, Kim YM, Choi HH, et al. Prevalence and clinical characteristics of gastroesophageal reflux disease and reflux esophagitis in chuncheon city-health care examination study. Korean J Med 2008; 74: 385-90.

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