Korean J Fam Pract. 2017; 7(4): 507-512  https://doi.org/10.21215/kjfp.2017.7.4.507
Risk Factors Associated with Carotid Intima-Media Thickness in Obese Adults
Hongseok Ki, Kyunam Kim*, Seon Yeong Lee, Jongwoo Kim, Junehyung Yoon, Mijeong Kang
Department of Family Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea
Kyunam Kim
Tel: +82-2-950-1150, Fax: +82-2-950-1153
E-mail: KIMKN@paik.ac.kr
Received: July 8, 2016; Revised: September 17, 2016; Accepted: September 23, 2016; Published online: August 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Carotid intima-media thickness (CIMT) is a recommended predictor for the probability of cardiovascular disease. One of the risk factors of cardiovascular disease is obesity associated with CIMT. We found this study is to investigate the independent factors affecting the changes of carotid intima-media thickness, including cholesterol ratio, in obese adults.
Methods: The study included 1,711 subjects (1,402 male, 309 female; aged 48.3 years) who had CIMT evaluated between January 2010 and December 2015 at a health promotion center. We divided the population into two groups according to body mass index (BMI): obese group (n=1,213, BMI ≥25 kg/m2) and non-obese group (n=498). We measured blood pressure, serum lipid profile, cholesterol ratio, white blood cell count, erythrocyte sedimentation rate, neutrophil-lymphocyte ratio, high sensitive C-reactive protein, and fasting blood glucose. Subsequently, CIMT was measured using high-resolution B-mode ultrasonography.
Results: CIMT was statistically different between the two groups (0.80±0.15 mm versus 0.76±0.18 mm, P<0.05). A multivariate regression analysis in the obese group revealed that age (β=0.395), BMI (β=0.138), total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio (β=0.070), lowdensity lipoprotein cholesterol (LDL-C)/HDL-C ratio (β=0.065), HDL-C/LDL-C ratio (β=-0.092), and HDL-C (β=-0.089) were independently associated with CIMT (P<0.05). However, the only factor for the non-obese group was age (β=0.413). Inflammatory markers did not show statistically significant correlations with CIMT in either group.
Conclusion: This study suggests that age, BMI, and TC/HDL-C ratio may be risk factors associated with CIMT in obese adults.
Keywords: Carotid Intima-Media Thickness; Age; Body Mass Index; High Density Lipoprotein Cholesterol
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