Korean J Fam Pract. 2017; 7(4): 563-568  https://doi.org/10.21215/kjfp.2017.7.4.563
Utilization Pattern of Anti-Hypertensive Medications according to Comorbidities in a Hospital-Based Family Medicine Practice
Boram Lim, Eunkyo Kang, Seung-hyun Yoo, Sung Sunwoo*
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Sung Sunwoo
Tel: +82-2-3010-3810, Fax: +82-2-3010-3815
E-mail: sws@amc.seoul.kr
Received: June 22, 2016; Revised: October 4, 2016; Accepted: October 21, 2016; Published online: August 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The prevalence of hypertension (HTN) in Korea has been estimated to be 30.4%, and HTN is the most common comorbidity in patients with diabetes mellitus (DM). The objective of this study was to examine recent trends in antihypertensive drug prescription in a hospital-based family medicine practice. In addition, we evaluated whether these drug utilization patterns follow the recommendations of the latest guidelines for the management of HTN.
Methods: We analyzed the utilization pattern of antihypertensive medications for patients with established HTN (n=964). We reviewed the medical records of patients who visited the outpatient clinic of the Department of Family Medicine of a Asan Medical Center between April 2013 and December 2013. A chi-square test was performed to evaluate the difference in the use of antihypertensive drugs according to comorbidities.
Results: The patients diagnosed as having both HTN and DM were more likely to be treated with combination therapies than those diagnosed as having HTN alone (P=0.003). The most common class of antihypertensive medication prescribed was angiotensin-receptor blockers (ARBs), followed by calcium channel blockers (CCBs), diuretics, and beta-blockers. As monotherapy, ARBs were the most common choice, followed by CCBs. Furthermore, the prescription rate of ARBs was significantly higher in the DM patients. In the patients who received combination therapies, combinations that included ARBs were the most frequent.
Conclusion: The utilization pattern of antihypertensive medications in a hospital-based family medicine practice adheres to the latest guidelines for the management of HTN.
Keywords: Hypertension; Diabetes Mellitus; Drug Utilization Pattern; Primary Care
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