Korean J Fam Pract. 2017; 7(6): 909-914  https://doi.org/10.21215/kjfp.2017.7.6.909
The Relationship between Triglyceride, Triglyceride to High Density Lipoprotein Cholesterol Ratio and Brachial Ankle Pulse Wave Velocity among Healthy Adults
Jae Hyun Youn, Ji Hoon Jung, Jung Hyun Kim*, Hyun Woo Kim, Byung Shik Cho, Sun Whan Kim, Seung Jin Jung, Dong Won Lee, Sang Hyun Cho
Department of Family Medicine, Hana General Hospital, Cheongju, Korea
Jung Hyun Kim
Tel: +82-43-230-6555, Fax: +82-43-235-5300
E-mail: astrobass@hanmail.net
Received: May 15, 2017; Revised: August 7, 2017; Accepted: August 15, 2017; Published online: December 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: This study investigated the correlation between triglyceride (TG) or the triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio and the brachial ankle pulse wave velocity (baPWV), which is widely used as an indirect measure of atherosclerosis.
Methods: The study included 1,331 adults (721 men, 610 women) aged between 20 and 65 years with no underlying disease, who underwent baPWV measurement at a general health checkup between May and October 2015. Multiple linear stepwise regression analysis was performed for TG and the TG/HDL-C ratio, using the results of univariate correlation analysis between baPWV and body measurements and biochemical parameters as variables, in addition to age, alcohol use, and smoking history.
Results: There was a significant difference in baPWV according to sex (male>female), and a positive correlation was found between baPWV and TG or the TG/HDL-C ratio in univariate analysis. Regression analysis of TG or the TG/HDL-C ratio and baPWV, after correction by calibrating all variables, showed β=0.078 and P=0.046 for TG and β=0.1 and P=0.004 for the TG/HDL-C ratio for men. For women, β=0.124 and P<0.001 for TG and β=0.112 and P=0.001 for the TG/HDL-C ratio. The results showed a significant relationship in both men and women.
Conclusion: There was a significant relationship between TG or the TG/HDL-C ratio and baPWV after controlling for demographic factors in adults without underlying disease.
Keywords: Arterial Stiffness; Brachial Ankle Pulse Wave Velocity; Triglyceride; Triglyceride to High Density Lipoprotein Cholesterol Ratio
References
  1. Scuteri A, Cunha PG, Rosei EA, Badariere J, Bekaert S, Cockcroft JR, et al. Arterial stiffness and influences of the metabolic syndrome: a cross-countries study. Atherosclerosis 2014; 233: 654-60.
    Pubmed KoreaMed CrossRef
  2. Scuteri A, Tesauro M, Appolloni S, Preziosi F, Brancati AM, Volpe M. Arterial stiffness as an independent predictor of longitudinal changes in cognitive function in the older individual. J Hypertens 2007; 25: 1035-40.
    Pubmed CrossRef
  3. Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation 2010; 121: 505-11.
    Pubmed KoreaMed CrossRef
  4. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 2010; 55: 1318-27.
    Pubmed CrossRef
  5. Wang KL, Cheng HM, Sung SH, Chuang SY, Li CH, Spurgeon HA, et al. Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study. Hypertension 2010; 55: 799-805.
    Pubmed KoreaMed CrossRef
  6. Cho SB, Choi HJ, Jang HY, Lee KB, Im IJ, Kim HJ. Factors associated with cardio-ankle vascular index in adults aged over 40 years. Korean J Fam Pract 2016; 6: 410-5.
    CrossRef
  7. Sugawara J, Tanaka H. Brachial-ankle pulse wave velocity: myths, misconceptions, and realities. Pulse (Basel) 2015; 3: 106-13.
    Pubmed KoreaMed CrossRef
  8. Vlachopoulos C, Aznaouridis K, Terentes-Printzios D, Ioakeimidis N, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with brachial-ankle elasticity index: a systematic review and meta-analysis. Hypertension 2012; 60: 556-62.
    Pubmed CrossRef
  9. Wilkinson I, Cockcroft JR. Cholesterol, lipids and arterial stiffness. Adv Cardiol 2007; 44: 261-77.
    Pubmed CrossRef
  10. Wen JH, Zhong YY, Wen ZG, Kuang CQ, Liao JR, Chen LH, et al. Triglyceride to HDL-C ratio and increased arterial stiffness in apparently healthy individuals. Int J Clin Exp Med 2015; 8: 4342-8.
    Pubmed KoreaMed
  11. Shin JW, Seok SJ, Lee GH, Choi SC, Hyun KY. Correlation between arterial stiffness and physiological parameters. Korean J Health Serv Manag 2013; 7:71-82.
    CrossRef
  12. Fischer GM, Swain ML. Influence of contraceptive and other sex steroids on aortic collagen and elastin. Exp Mol Pathol 1980; 33: 15-24.
    CrossRef
  13. Miura S, Tanaka E, Mori A, Toya M, Takahashi K, Nakahara K, et al. Hormone replacement therapy improves arterial stiffness in normotensive postmenopausal women. Maturitas 2003; 45: 293-8.
    CrossRef
  14. Papaioannou TG, Karatzi K, Psaltopoulou T, Tousoulis D. Arterial ageing:major nutritional and life-style effects. Ageing Res Rev 2017; 37: 162-3.
    Pubmed CrossRef
  15. Kwon YJ, Chung TH, Shim JY, Lee YJ. The association of pulse pressure with metabolic syndrome in Korean elderly: a nationwide population-based study. Diabetes Res Clin Pract 2017; 123: 75-81.
    Pubmed CrossRef
  16. Kim JY, Park JB, Kim DS, Kim KS, Jeong JW, Park JC, et al. Gender difference in arterial stiffness in a multicenter cross-sectional study: the Korean arterial aging study (KAAS). Pulse (Basel) 2014; 2: 11-7.
    Pubmed KoreaMed CrossRef
  17. Munakata M. Brachial-ankle pulse wave velocity: background, method, and clinical evidence. Pulse (Basel) 2016; 3: 195-204.
    Pubmed KoreaMed CrossRef
  18. Urbina EM, Khoury PR, McCoy CE, Dolan LM, Daniels SR, Kimball TR. Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents, and young adults. Pediatrics 2013; 131: e1082-90.
    Pubmed KoreaMed CrossRef


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