Korean J Fam Pract. 2018; 8(1): 15-20  https://doi.org/10.21215/kjfp.2018.8.1.15
The Correlation between Colon Polyps and Metabolic Syndrome Parameters, Serum Uric Acid Level in Health Screen Examinees
Ah-ra Koh*, Chun-hwan Kim, Jun-ho Bang, Kwang-wook Jung, Hee-kwon Yu
Department of Family Medicine, Dongsuwon General Hospital, Suwon, Korea
Ah-ra Koh
Tel: +82-31-210-0114, Fax: +82-31-210-0140
E-mail: ahrakoh16@gmail.com
ORCID: http://orcid.org/0000-0001-8146-8286
Received: March 6, 2017; Revised: June 4, 2017; Accepted: June 23, 2017; Published online: February 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Adenomatous polyps of the colon are precancerous lesions. Whether hyperuricemia represents an independent risk factor for colon cancer is controversial. Studies have indicated a relationship between colon cancer and metabolic syndrome. The aim of this study was to determine whether metabolic syndrome parameters and hyperuricemia are risk factors for colon polyps and whether uric acid level is a predictive factor.
Methods: We retrospectively reviewed the medical records of patients with colon polyps who visited the General Hospital Health Promotion Center in Suwon and underwent colonoscopic examination between January 2011 and December 2014. A total of 1,435 asymptomatic adults were included. We analyzed the odds ratios and 95% confidence intervals for colon polyps by using a multivariable logistic regression analysis. All the analyses were conducted using IMB SPSS 22.0.
Results: In the 1,435 patients, the prevalence of colon polyps was 21.3% (n=305). t-test revealed that the prevalence of colon polyps was higher in the patients with high triglyceride level, body mass index, and abdominal circumference. However, in the multiple regression analysis, the risk of colon polyps was not significantly associated with metabolic syndrome parameters and serum uric acid level.
Conclusion: The occurrence of colon polyps was not associated with metabolic syndrome parameters and serum uric acid level in the health screening examinees in this study.
Keywords: Colonic Polyps; Metabolic Syndrome; Uric Acid
  1. Winawer SJ, Zauber AG, Ho MN, O’Brien MJ, Gottlieb LS, Sternberg SS, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993; 329: 1977-81.
    Pubmed CrossRef
  2. Borritz M, Rugulies R, Bjorner JB, Villadsen E, Mikkelsen OA, Kristensen TS. Burnout among employees in human service work: design and baseline findings of the PUMA study. Scand J Public Health 2006; 34: 49-58.
    Pubmed CrossRef
  3. International Agency for Research Cancer. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012 [Internet]. Lyon: International Agency for Research cancer; 2012. [cited 2012 Apr 1]. Abailable from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
  4. Jung KW, Won YJ, Kong HJ, Oh CM, Cho H, Lee DH, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2012. Cancer Res Treat 2015; 47: 127-41.
    Pubmed KoreaMed CrossRef
  5. Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology 2010; 138: 2029-43.e10.
    Pubmed KoreaMed CrossRef
  6. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-52.
    Pubmed CrossRef
  7. Fearnhead NS, Wilding JL, Bodmer WF. Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis. Br Med Bull 2002; 64: 27-43.
    Pubmed CrossRef
  8. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
  9. Terkeltaub R. Update on gout: new therapeutic strategies and options. Nat Rev Rheumatol 2010; 6: 30-8.
    Pubmed CrossRef
  10. Cigolini M, Targher G, Tonoli M, Manara F, Muggeo M, De Sandre G. Hyperuricaemia:relationships to body fat distribution and other components of the insulin resistance syndrome in 38-year-old healthy men and women. Int J Obes Relat Metab Disord 1995; 19: 92-6.
  11. Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH. Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol 2005; 20: 1410-5.
    Pubmed CrossRef
  12. Park SH. Internal medicine department of catholic university of Korea, colon polyps. Korean J Intern Med 2010; 79: S491-4.
  13. Lee WC, Neugut AI, Garbowski GC, Forde KA, Treat MR, Waye JD, et al. Cigarettes, alcohol, coffee, and caffeine as risk factors for colorectal adenomatous polyps. Ann Epidemiol 1993; 3: 239-44.
  14. Bird CL, Frankl HD, Lee ER, Haile RW. Obesity, weight gain, large weight changes, and adenomatous polyps of the left colon and rectum. Am J Epidemiol 1998; 147: 670-80.
    Pubmed CrossRef
  15. Kim MC, Kim DH, Jeong TH. Risk factors of colorectal polyps in Korean adults. J Korean Acad Fam Med 2002; 23: 890-6.
  16. Seow A, Yuan JM, Koh WP, Lee HP, Yu MC. Diabetes mellitus and risk of colorectal cancer in the Singapore Chinese health study. J Natl Cancer Inst 2006; 98: 135-8.
    Pubmed CrossRef
  17. Ishino K, Mutoh M, Totsuka Y, Nakagama H. Metabolic syndrome: a novel high-risk state for colorectal cancer. Cancer Lett 2013; 334: 56-61.
    Pubmed CrossRef
  18. Yun JW, Mook KJ, Lee WY, Kim SW. Plasma uric acid concentrations represent the degree of metabolic control and diabetic complications in type 2 diabetes. Korean J Med 2003; 64: 78-84.
  19. Saggiani F, Pilati S, Targher G, Branzi P, Muggeo M, Bonora E. Serum uric acid and related factors in 500 hospitalized subjects. Metabolism 1996; 45:1557-61.
  20. Ishizaka N, Ishizaka Y, Toda E, Nagai R, Yamakado M. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 2005; 25: 1038-44.
    Pubmed CrossRef
  21. Desgrippes R, Beauchamp C, Henno S, Bouguen G, Siproudhis L, Bretagne JF. Prevalence and predictive factors of the need for surgery for advanced colorectal adenoma. Colorectal Dis 2013; 15: 683-8.
    Pubmed CrossRef
  22. Nilsen TI, Vatten LJ. Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia hypothesis. Br J Cancer 2001; 84: 417-22.
    Pubmed KoreaMed CrossRef

This Article