Korean J Fam Pract. 2018; 8(1): 32-38  https://doi.org/10.21215/kjfp.2018.8.1.32
The Effect of Regular Exercise on the Increase of White Blood Cell Count by Smoking Status in Adult Men
Kyuha Lee, Soshin Kye*, Juhyun Lee, Kichul Kim, Yeonhee Kim, Mina Cho, Hankyu Choi, Sejin Oh
Department of Family Medicine, National Police Hospital, Seoul, Korea
Soshin Kye
Tel: +82-2-3400-1395, Fax: +82-2-3400-1366
E-mail: soskye@police.go.kr
ORCID: http://orcid.org/0000-0003-0687-6866
Received: March 9, 2017; Revised: June 27, 2017; Accepted: July 17, 2017; Published online: February 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: It is known that an increase in the white blood cell (WBC) count is related to the incidence of and mortality associated with various diseases. However, there is little research on the effect of regular exercise on the increase in WBC count according to smoking status. This study investigated the relationship between regular exercise and the WBC count according to smoking status in adult men.
Methods: We completed questionnaires and performed anthropometry and blood tests on 1,529 men aged 30 to 59. Differences in baseline characteristics according to smoking status and relationships between quartiles of WBC counts and related factors were analyzed using one-way analysis of variance or chi-square tests. We performed a t-test to compare WBC counts according to smoking status and participation in regular exercise. To determine the independent effect of regular exercise on an increase in the WBC count, we performed multiple logistic regression analysis and analysis of covariance after adjusting for related factors, stratified by smoking status.
Results: Mean WBC counts in the current smoker group were higher than those in the never smoked group and ex-smoker group (P<0.001). However, WBC counts significantly decreased with regular exercise in the current smoker group, and the decrease remained significant after adjustment for related factors (P=0.002).
Conclusion: Considering the relationship of the WBC count with the incidence of and mortality associated with various diseases, regular exercise as well as smoking cessation is especially important in current smokers.
Keywords: Smoking; Exercise; Leukocyte Count; Men
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