Korean J Fam Pract. 2018; 8(1): 147-150  https://doi.org/10.21215/kjfp.2018.8.1.147
Do Benign Pancreatic Cysts Increase the Incidence Risk of Pancreatic Cancer?: For Korean Aged over 40 Years
Yong-hwan Kim1, Yong-gwang Kim1, Yohan Jung1, Hyun-gyu Shin1, Mi-hye Kim1, Jaejun Dong2, Jae Yong Shim1, Duk-chul Lee1,*
1Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine; 2Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Duk-chul Lee
Tel: +82-2-2019-3483, Fax: +82-2-3463-3287
E-mail: FAITH@yuhs.ac
ORCID: http://orcid.org/0000-0001-9166-1813
Received: September 9, 2016; Revised: September 27, 2016; Accepted: October 2, 2016; Published online: February 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Whether pancreatic cysts such as mucinous cystic neoplasm and intraductal papillary mucinous neoplasm have malignant potential is known. However, whether patients with benign pancreatic cysts have a higher risk of pancreatic cancer (PaCa) has not been established yet.
Methods: We evaluated data from the National Health Insurance Service-National Sample Cohort (2002–2006) of the Korean National Health Insurance Service. Patients with pancreatic cysts detected on computed tomography/magnetic resonance imaging were identified using the Korean Classification of Diseases, 6th Edition. Patients aged >40 years with and those without pancreatic cystic lesions were followed up until 2010 (389,777 patients).
Results: During the study period, PaCa was diagnosed in 2 of 71 patients with pancreatic cysts and in 1,605 of 389,706 patients without pancreatic cyst. The incidence rates of PaCa were 2.82% and 0.41%, respectively. The hazard ratio of PaCa in all the patients with cysts was 9.839 (95% confidence interval, 2.461–39.332; P=0.0012) when compared with the rest of the patients without cysts.
Conclusion: Patients aged >40 years with pancreatic cysts have a significantly higher risk of PaCa.
Keywords: Pancreatic Cysts; Pancreatic Neoplasms; Incidence; Risk
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