Korean J Fam Pract. 2018; 8(3): 354-358  https://doi.org/10.21215/kjfp.2018.8.3.354
Relationship between Serum Vitamin D Concentration and Pulmonary Function in Obese Nonsmokers
Hyerin Shin, Seon Yeong Lee*, Kyunam Kim, Dae Youn Kim, Jihye Won, Jeongki Paek
Department of Family Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Seon Yeong Lee
Tel: +82-2-950-1150, Fax: +82-2-950-1153
E-mail: sylee@paik.ac.kr
ORCID: http://orcid.org/0000-0002-8274-3654
Received: June 5, 2017; Revised: September 8, 2017; Accepted: September 13, 2017; Published online: June 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Low blood vitamin D levels have been postulated to be a risk factor for poor lung function in many studies. There has also been an increase in the number of studies over the past decade that have identified an association between obesity and vitamin D deficiency; both are recognized as major public health issues worldwide. The aim of this study was to investigate the relationship of the current vitamin D status with lung function in obese individuals.
Methods: We used cross-sectional data from 2,261 participants who underwent evaluation of 25-hydroxyvitamin D (25(OH)D) levels and lung function tests at a health promotion center from January 2016 to November 2016. We included individuals with body mass index of 25 kg/m2 or greater and who exhibited no abnormalities on chest radiography. We excluded smokers and ex-smokers who had discontinued smoking within 15 years.
Results: After adjustments for sex, age, and height, forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1) showed positive linear relationships with serum 25(OH)D (P=0.049 and P=0.043, respectively). However, FVC/FEV1 had no significant relationship with serum 25(OH)D (P=0.668).
Conclusion: This study showed a significant positive relationship between serum concentrations of 25(OH)D and respiratory function in obese individuals.
Keywords: Vitamin D; Obesity; Respiratory Function Tests
  1. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
    Pubmed CrossRef
  2. Prentice A. Vitamin D deficiency: a global perspective. Nutr Rev 2008; 66(10 Suppl 2): S153-64.
    Pubmed CrossRef
  3. Afzal S, Brøndum-Jacobsen P, Bojesen SE, Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol 2014; 2: 298-306.
  4. Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala NB, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas 2010; 65: 225-36.
    Pubmed CrossRef
  5. Litonjua AA. Vitamin D deficiency as a risk factor for childhood allergic disease and asthma. Curr Opin Allergy Clin Immunol 2012; 12: 179-85.
    Pubmed KoreaMed CrossRef
  6. Nnoaham KE, Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol 2008; 37: 113-9.
    Pubmed CrossRef
  7. Berry DJ, Hesketh K, Power C, Hyppönen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr 2011; 106: 1433-40.
    Pubmed CrossRef
  8. Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005; 128: 3792-8.
    Pubmed CrossRef
  9. Choi CJ, Seo M, Choi WS, Kim KS, Youn SA, Lindsey T, et al. Relationship between serum 25-hydroxyvitamin D and lung function among Korean adults in Korea national health and nutrition examination survey (KNHANES), 2008-2010. J Clin Endocrinol Metab 2013; 98: 1703-10.
    Pubmed CrossRef
  10. Shaheen SO, Jameson KA, Robinson SM, Boucher BJ, Syddall HE, Sayer AA, et al. Relationship of vitamin D status to adult lung function and COPD. Thorax 2011; 66: 692-8.
    Pubmed CrossRef
  11. Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev 2015; 16: 341-9.
    Pubmed CrossRef
  12. Rhee SY, Park SW, Kim DJ, Woo J. Gender disparity in the secular trends for obesity prevalence in Korea: analyses based on the KNHANES 1998-2009. Korean J Intern Med 2013; 28: 29-34.
    Pubmed KoreaMed CrossRef
  13. World Health Organization. Prevention and management of osteoporosis:report of a WHO scientific group. Report of a WHO Scientific Group, Geneva, 2000. WHO Technical report series 921. Geneva: World Health Organization;2003.
  14. Ross AC; Institute of Medicine (U.S.). Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. DRI, dietary reference intakes: calcium, vitamin D. Washington, DC: National Academies Press; 2011.
  15. Pearce SH, Cheetham TD. Diagnosis and management of vitamin D deficiency. BMJ 2010; 340: b5664.
    Pubmed CrossRef
  16. Park HA, Kim SY. Recent advance on vitamin D. J Korean Med Assoc 2013;56: 310-8.
  17. Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis 1983; 127: 725-34.
  18. Kunisaki KM, Niewoehner DE, Singh RJ, Connett JE. Vitamin D status and longitudinal lung function decline in the lung health study. Eur Respir J 2011; 37: 238-43.
    Pubmed KoreaMed CrossRef
  19. Heine G, Niesner U, Chang HD, Steinmeyer A, Zügel U, Zuberbier T, et al. 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Eur J Immunol 2008; 38: 2210-8.
    Pubmed CrossRef
  20. Hartmann B, Heine G, Babina M, Steinmeyer A, Zügel U, Radbruch A, et al. Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response. Allergy 2011; 66: 540-8.
    Pubmed CrossRef
  21. Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoidresistant asthma patients. J Clin Invest 2006; 116: 146-55.
    Pubmed KoreaMed CrossRef
  22. Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol. 2009; 158: 20-5.
    Pubmed KoreaMed CrossRef
  23. Hu G, Cassano PA. Antioxidant nutrients and pulmonary function: the third national health and nutrition examination survey (NHANES III). Am J Epidemiol 2000; 151: 975-81.
    Pubmed CrossRef
  24. Klingberg E, Oleröd G, Konar J, Petzold M, Hammarsten O. Seasonal variations in serum 25-hydroxy vitamin D levels in a Swedish cohort. Endocrine 2015; 49: 800-8.
    Pubmed KoreaMed CrossRef

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