Korean J Fam Pract. 2018; 8(3): 473-476  https://doi.org/10.21215/kjfp.2018.8.3.473
A Study on Relationship between Bone Mineral Density and Metabolic Syndrome in Healthy Male and on Relevant Factors to Bone Mineral Density in Smokers
Han Sook Kim1, Sung-Goo Kang2,*, Sun Wook Hwang1, Hye Yeon Kim1
1Department of Family Medicine, St. Paul’s Hospital, College of Medicine, The Catholic University of Korea; 2Department of Family Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Sung-Goo Kang
Tel: +82-31-249-8308, Fax: +82-31-249-8253
E-mail: hippo94@naver.com
ORCID: http://orcid.org/0000-0003-4627-291X
Received: June 23, 2017; Revised: October 11, 2017; Accepted: October 19, 2017; Published online: June 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Osteoporosis in males has lower prevalence, awareness, and treatment rates than that in females. However, if fracture occurs, the injury is generally more serious in males. This study evaluated potential factors associated with loss of bone mineral density (BMD) in male smokers and analyzed its relationship with the metabolic syndrome.
Methods: The participants were 140 male adults who had undergone BMD testing at the Medical Examination Saint Paul’s Hospital. We selected medical records retrospectively and extracted data regarding BMD, smoking history, criteria for metabolic syndrome diagnosis, vitamin D levels, and routine blood tests. The association between BMD and metabolic syndrome was evaluated. In addition, relevant factors associated with BMD in male smokers were analyzed.
Results: Aging and metabolic syndrome in male smokers showed a significant association with BMD on multiple regression analysis (P=0.044 and P=0.027, respectively).
Conclusion: BMD in males showed a positive association with metabolic syndrome and a negative relationship with aging.
Keywords: Male; Osteoporosis; Bone Density; Smokers; Metabolic Syndrome
  1. Ha YC. Epidemiology of osteoporosis in Korea. J Korean Med Assoc 2016;59: 836-41.
  2. Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int 1994; 4: 368-81.
    Pubmed CrossRef
  3. Choi YJ, Oh HJ, Kim DJ, Lee Y, Chung YS. The prevalence of osteoporosis in Korean adults aged 50 years or older and the higher diagnosis rates in women who were beneficiaries of a national screening program: the Korea National Health and Nutrition Examination Survey 2008-2009. J Bone Miner Res 2012; 27: 1879-86.
    Pubmed CrossRef
  4. Kim Y, Kim JH, Cho DS. Gender difference in osteoporosis prevalence, awareness and treatment: based on the Korea National Health and Nutrition Examination Survey 2008~2011. J Korean Acad Nurs 2015; 45: 293-305.
    Pubmed CrossRef
  5. Zhou J, Zhang Q, Yuan X, Wang J, Li C, Sheng H, et al. Association between metabolic syndrome and osteoporosis: a meta-analysis. Bone 2013; 57: 30-5.
    Pubmed CrossRef
  6. Indhavivadhana S, Rattanasrithong P. The relationship between bone mineral density and metabolic syndrome in peri- and post-menopausal Thai women. Arch Gynecol Obstet 2015; 292: 1127-33.
    Pubmed CrossRef
  7. Yang L, Lv X, Wei D, Yue F, Guo J, Zhang T. Metabolic syndrome and the risk of bone fractures: a Meta-analysis of prospective cohort studies. Bone 2016;84: 52-6.
    Pubmed CrossRef
  8. Ensrud KE, Blackwell TL, Cawthon PM, Bauer DC, Fink HA, Schousboe JT, et al. Degree of trauma differs for major osteoporotic fracture events in older men versus older women. J Bone Miner Res 2016; 31: 204-7.
    Pubmed KoreaMed CrossRef
  9. Kang HT, Kim SY, Kim J, Kim J, Kim J, Park HY, et al. Clinical practice guideline of prevention and treatment for metabolic syndrome. Korean J Fam Pract 2015; 5: 375-420.
  10. Campion JM, Maricic MJ. Osteoporosis in men. Am Fam Physician 2003;67: 1521-6.
  11. Yoon SP, Lee SH, Park BM, Song KS, Jang G, Lee BS, et al. Effect of smoking on osteoporotic vertebral fracture in postmenopausal women. J Korean Soc Spine Surg 2016; 23: 1-6.
  12. Kim KH, Lee CM, Park SM, Cho B, Chang Y, Park SG, et al. Secondhand smoke exposure and osteoporosis in never-smoking postmenopausal women: the Fourth Korea National Health and Nutrition Examination Survey. Osteoporos Int 2013; 24: 523-32.
    Pubmed CrossRef
  13. Fujita Y, Iki M. Risk factors for osteoporosis in men from the Fujiwara-kyo osteoporosis risk in men study. Clin Calcium 2016; 26: 1031-7.

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