Korean J Fam Pract. 2018; 8(5): 771-774  https://doi.org/10.21215/kjfp.2018.8.5.771
Factors Associated with Neoplastic Transformation in Gastric Polyps
Booyoon Cheung1, Myeong Su Chu2, Ji-Hyun Kim1, Chung Kang1, Seunghee Kim1, Suwha Lee1,*
1Department of Family Medicine, 2Department of Gastroenterology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Suwha Lee
Tel: +82-42-220-9523, Fax: +82-42-220-9564
E-mail: drimp@naver.com
ORCID: http://orcid.org/0000-0002-7830-9118
Received: July 27, 2017; Revised: September 19, 2017; Accepted: October 7, 2017; Published online: October 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Risk factors for the development of stomach cancer include genetic or familial syndromes, gastric colonization by Helicobacter pylori, and conditions resulting in gastric dysplasia. However, risk factors for malignant transformation of benign gastric ulcers, fundic gland polyps, and the most common type, hyperplastic polyps (HPs), have not been fully revealed. The aim of this study was to identify the incidence of dysplasia and cancer associated with gastric HPs and the factors associated with their neoplastic transformation.
Methods: Between January 2010 and November 2016, data from 683 patients with gastric HPs who underwent endoscopic removal or surgical resection were analyzed retrospectively.
Results: Neoplastic transformation was found in 28 cases (4.1%) of 683 patients with gastric HPs including 4 (0.6%), 5 (0.7%), and 17 (2.5%) cases of low-grade dysplasia, high-grade dysplasia, and adenocarcinoma, respectively. Neoplastic transformations were significantly associated with polyps >2 cm in size (n=65 [9.5%] vs. n=618 [90.4%], P=0.049). However, no significant correlation was found between neoplastic transformation and age, sex, number of polyps detected per patient, location of polyps, or H. pylori infection.
Conclusion: Although the incidence of dysplasia and cancer in gastric HPs is still very low, malignant transformation of gastric HPs had a significant correlation with polyps >2 cm in size. Therefore, when gastric HPs larger than 2 cm are detected during screening, endoscopic polypectomy or surgical resection should be considered to reduce the risk of neoplastic transformation.
Keywords: Stomach; Cancer; Polyp; Dysplasia; Neoplastic; Transformation
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