Korean J Fam Pract. 2018; 8(6): 820-825  https://doi.org/10.21215/kjfp.2018.8.6.820
Effect of Albuminuria on Silent Lacunar Infarction
Hyung Jun Park1, Hyung-Min Kwon2, Jae-Sung Lim3, Sang Hyuck Kim4,5,*, Jin-Ho Park1,*
1Department of Family Medicine, Seoul National University Hospital; 2Department of Neurology, SMG-SNU Boramae Medical Center, Seoul; 3Department of Neurology, Hallym University Sacred Heart Hospital, Anyang; 4Health Screening and Promotion Center, 5Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Jin-Ho Park
Tel: +82-2-2072-0865, Fax: +82-2-766-3276
E-mail: kkolzzi0@gmail.com
ORCID: http://orcid.org/0000-0002-3942-6813
Sang Hyuck Kim
Tel: +82-31-787-7808, Fax: +82-31-787-4834
E-mail: fromage5@naver.com
ORCID: http://orcid.org/0000-0002-4851-396X
Received: August 18, 2017; Revised: September 22, 2017; Accepted: October 7, 2017; Published online: December 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Silent lacunar infarction (SLI) is a risk factor for progression to overt cerebrovascular disease (CVD). Albuminuria is used for the evaluation of renal dysfunction. Some studies showed an association between cerebral microbleeding and renal dysfunction, but the results were inconsistent. Therefore, this study aimed to examine the association between albuminuria and SLI.
Methods: A total of 2,211 subjects without overt CVD who underwent brain magnetic resonance imaging were analyzed in the health screening data of Seoul National University Hospital. SLI was defined as 3–5 mm area of focal subcortical infarction. Albuminuria was defined as a urine albumin-tocreatinine ratio ≥30 mg/g. Multivariate logistic regression analysis was performed.
Results: Albuminuria is associated with increased risk of SLI (adjusted odds ratio, 1.78; 95% confidence interval, 1.12–2.82). Variables associated with SLI included age (adjusted odds ratio, 1.08; 95% confidence interval, 1.06–1.11) and hypertension (adjusted odds ratio, 1.66; 95% confidence interval, 1.20–2.31).
Conclusion: The findings suggest that patients with albuminuria should be considered for CVD risk evaluation and screening.
Keywords: Cerebrovascular Disorders; Stroke, Lacunar; Albuminuria; Hypertension; Aged


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