Korean J Fam Pract. 2018; 8(6): 877-881  https://doi.org/10.21215/kjfp.2018.8.6.877
The Association between Thyroid Stimulating Hormone and Metabolic Syndrome in Korean: The 6th Korean National Health and Nutrition Examination Survey (2015)
Je-Young Lee, Ji-Hyun Kim*, Mi-Kyeong Ju, Ji-Seok Kim, Myung-Hee Park
Department of Family Medicine, BHS Hanseo Hospital, Busan, Korea
Ji-Hyun Kim
Tel: +82-70-7321-0270, Fax: +82-51-751-4372
E-mail: kjh77960@hanmail.net
ORCID: http://orcid.org/0000-0002-6447-2571
Received: January 11, 2018; Revised: May 11, 2018; Accepted: September 11, 2018; Published online: December 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Thyroid dysfunction is associated with abnormal lipid metabolism. Thyroid stimulating hormone (TSH) is a marker of thyroid function and is correlated with metabolic syndrome. This study aimed to determine the relationship between TSH concentration and lipid metabolism, and to examine the effect of TSH on the diagnostic criteria for metabolic syndrome.
Methods: We used the data of 2,209 individuals aged above 10 years from the 6th National Health and Nutrition Survey (2015). Chi-square test and one-way ANOVA were performed to analyze the general characteristics of the subjects. Multiple linear regression analysis was used to examine the correlation between serum TSH concentration and the indicators of metabolic syndrome. Logistic regression analysis was used to examine the prevalence of metabolic syndrome in three groups of patients who were classified according to their TSH concentration.
Results: After adjustment for age, sex, household income, physical activity, stress perception, sleep duration, drinking, and smoking, a significant positive correlation was observed between serum lipid concentration and TSH concentration. The prevalence of metabolic syndrome increased with increasing TSH concentration in all three groups of patients.
Conclusion: Serum lipid concentration and prevalence of metabolic syndrome increase with increasing concentration of TSH.
Keywords: Thyroid Stimulating Hormone; Metabolic Syndrome; Total Cholesterol; Triglyceride; Low Density Lipoprotein Cholesterol
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