Korean J Fam Pract. 2018; 8(6): 896-903  https://doi.org/10.21215/kjfp. 2018.8.6.896
The Associations between Number of Pregnancy, Age at Childbirth and Dyslipidemia According to Menopause Status in Female Adults with Fertility
Sil-Bi Kang1,2, Mi Ah Han3,*, Jong Park3, So Yeon Ryu3
1Department of Public Health, Graduate School of Health Science, Chosun University; 2Department of Nursing, Kwangju Christian Hospital; 3Department of Preventive Medicine, School of Medicine, Chosun University, Gwangju, Korea
Mi Ah Han
Tel: +82-62-230-6481, Fax: +82-62-225-8293
E-mail: mahan@chosun.ac.kr
ORCID: http://orcid.org/0000-0003-1213-6952
Received: January 15, 2018; Revised: May 23, 2018; Accepted: June 18, 2018; Published online: December 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

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Abstract
Background: Reproductive factors such as pregnancy, childbirth, and menopause can have an effect on metabolic diseases in women. The objectives of this study were to investigate the associations between number of pregnancies, age at childbirth, and dyslipidemia according to menopausal status in Korean female adults with fertility.
Methods: The study subjects were 6,194 female adults aged ≥19 years with fertility who participated in the 6th Korea National Health and Nutrition Examination Survey (2013–2015). Hypercholesterolemia, hypertriglyceridemia, decreased high-density lipoprotein (HDL) cholesterolemia, and increased low-density lipoprotein cholesterolemia were assessed using health interviews and examination data. Frequency analysis, chi-square tests, and t-tests were used for statistical analysis. Multiple logistic regression was used to investigate the associations between number of pregnancies, age at childbirth, and dyslipidemia according to menopausal status.
Results: In postmenopausal women, the odds ratio (OR) for hypertriglyceridemia was significantly higher in women who had a first delivery at age <19 years compared to those who delivered at 25–29 years (OR=1.83, 95% confidence interval [Cl]=1.08–3.10). The lower the age at first childbirth, the higher the risk of hypertriglyceridemia (P-trend=0.021). First childbirth at 20–24 years was associated with increased OR for decreased HDL cholesterolemia (OR=1.57, 95% Cl=1.18–2.08) compared to that with first childbirth at 25–29 years.
Conclusion: Age at first childbirth was associated with hypertriglyceridemia and decreased HDL cholesterolemia in postmenopausal women. Further study is needed to identify the biologic mechanisms between age at childbirth and dyslipidemia and the differences in the types of lipids affected.
Keywords: Dyslipidemias; Fertility; Health Surveys; Maternal Age; Menopause; Pregnancy


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