Korean J Fam Pract 2019; 9(2): 167-172  https://doi.org/10.21215/kjfp.2019.9.2.167
The Relationship between Serum Uric Acid and Ankle Brachial Index in Korean Men
Deok Hyun Shin, Sungmoon Cho, Jiin Jung, Seon Yeong Lee*, Kyunam Kim, Jongwoo Kim, Jeongki Paek
Department of Family Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Seon Yeong Lee, Tel: +82-2-950-1150, Fax: +82-2-950-1153, E-mail: sylee@paik.ac.kr, ORCID: http://orcid.org/0000-0002-8274-3654
Received: July 19, 2018; Revised: August 22, 2018; Accepted: March 13, 2019; Published online: April 20, 2019.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Elevated serum uric acid (UA) level is a known risk factor for atherosclerotic diseases, including peripheral arterial disease (PAD). PAD is easily diagnosed by determining the ankle-brachial index (ABI). The relationship between serum UA and subclinical atherosclerotic diseases remains controversial. We therefore aimed to explore an independent association between UA and ABI in healthy Korean men.
Methods: A cross-sectional study was conducted in 664 male participants aged ≥19 years who visited our Center for Health Promotion. The ABI and serum UA were determined for all participants and the relationship between these parameters and between ABI and other variables was assessed with the Pearson correlation coefficient. Multiple regression analysis was conducted to determine an independent correlation between serum UA and ABI after adjustment for certain variables. Analysis of covariance was employed to identify a trend in the ABI relative to UA quartiles.
Results: The ABI correlated inversely with UA and variables such as body mass index, diastolic blood pressure, heart rate, total cholesterol, triglycerides, and low-density lipoprotein-cholesterol. UA showed an independent inverse correlation with the ABI after serial adjustment for these variables (β= -0.265, P<0.001). A decreasing trend in the ABI was observed with increasing UA quartile (P<0.001).
Conclusion: UA shows an independent inverse correlation with ABI in healthy Korean men.
Keywords: Uric Acid; Peripheral Arterial Disease; Atherosclerosis; Ankle Brachial Idex
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