Korean J Fam Pract. 2017; 7(3): 308-314  https://doi.org/10.21215/kjfp.2017.7.3.308
The Association of Depression and Cardiovascular Risk Factors in Korean Adults: The Sixth Korea National Health and Nutrition Examination Survey, 2014
Yo Han Jung, Hye Kyung Shin, Yong Hwan Kim, Hyun Gyu Shin, John Linton*
Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
John Linton
Tel: +82-2-2228-2330, Fax: +82-2-312-2846
E-mail: YOHAN@yuhs.ac
Received: March 18, 2016; Revised: August 30, 2016; Accepted: September 3, 2016; Published online: June 20, 2017.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Some studies have shown that depression increases the chances of developing risk factors of cardiovascular diseases (CVDs) and cerebrovascular disease. Few studies have examined Korean adults without overt CVD. This study investigated the cardiovascular risk factors associated with depression among Korean adults without overt CVD.
Methods: A total of 4,093 subjects without overt CVD from the Sixth Korean National Health and Nutrition Examination Survey were analyzed according to sex using univariate analysis and multivariate analysis. Depression was identified using a cut-off score of 10-points in the Patient Health Questionnaire-9 (PHQ-9).
Results: The overall prevalence of depression was 9.7% (males: 5.5%, females: 13.0%). In the analysis of the association between depression and each univariate analysis of risk factors, hypertension and dyslipidemia were statistically significant in females, but there was only a significant relationship in regards to dyslipidemia in males The associated risk factor for depression was dyslipidemia (odds ratio 1.546, 95% confidence interval 1.011–2.363) in males, but not in females in the multivariate analysis.
Conclusion: This study found that there is an association between dyslipidemia and depression in males, but not in females.
Keywords: Depression; Cardiovascluar Diseases; Hypertension; Diabetes Mellitus; Dyslipidemias; Obesity
References
  1. World Health Organization. Report of the joint WHO/FAO expert consultation - Diet, nutrition and the prevention of chronic diseases. Geneva:World Health Organization; 2003.
  2. Seoul National University College of Medicine. The epidemiological survey of mental disorders in Korea 2011. Seoul: Ministry of Health and Welfare;2012.
  3. Statistics Korea. The statistical result about cause of death at 2014 [Internet]. Daejeon: Statistics Korea; 2014 [cited 2016 Feb 26].
    Available from: http://www.index.go.kr/pota/main/EachDtlPageDetail.do?idx_cd=1012
    Pubmed KoreaMed
  4. Kannel WB, McGee D, Gordon T. A general cardiovascular risk profile: the Framingham Study. Am J Cardiol 1976; 38: 46-51.
    CrossRef
  5. Rozanski A, Blumenthal JA, Davidson KW, Saab PG, Kubzansky L. The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol 2005; 45: 637-51.
    Pubmed CrossRef
  6. Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J 2006;27: 2763-74.
    Pubmed CrossRef
  7. de Jonge P, Mangano D, Whooley MA. Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Psychosom Med 2007; 69: 735-9.
    Pubmed KoreaMed CrossRef
  8. Ziegelstein RC, Parakh K, Sakhuja A, Bhat U. Depression and coronary artery disease: is there a platelet link? Mayo Clin Proc 2007; 82: 1366-8.
    Pubmed CrossRef
  9. Yoo SJ, Jeong H. Diagnosis and treatment of adrenal insufficiency. Hanyang Med Rev 2012; 32: 203-12.
    CrossRef
  10. Weber-Hamann B, Werner M, Hentschel F, Bindeballe N, Lederbogen F, Deuschle M, et al. Metabolic changes in elderly patients with major depression:evidence for increased accumulation of visceral fat at follow-up. Psychoneuroendocrinology 2006; 31: 347-54.
    Pubmed CrossRef
  11. Brown ES, Varghese FP, McEwen BS. Association of depression with medical illness: does cortisol play a role? Biol Psychiatry 2004; 55: 1-9.
    CrossRef
  12. Brouwers C, Mommersteeg PM, Nyklíček I, Pelle AJ, Westerhuis BL, Szabó BM, et al. Positive affect dimensions and their association with inflammatory biomarkers in patients with chronic heart failure. Biol Psychol 2013; 92:220-6.
    Pubmed CrossRef
  13. Timonen M, Laakso M, Jokelainen J, Rajala U, Meyer-Rochow VB, KeinänenKiukaanniemi S. Insulin resistance and depression: cross sectional study. BMJ 2005; 330: 17-8.
    Pubmed KoreaMed CrossRef
  14. Choi JW, Cho JJ, Chang HM, Kim CW, Paek YJ, Song HJ, et al. Association between depression and cardiovascular risk factors in workers undergoing comprehensive medical examination in a university-based hospital. J Korean Acad Fam Med 2008; 29: 645-50.
  15. So ES. Cardiovascular disease risk factors associated with depression among Korean adults with coronary artery disease and cerebrovascular disease. Asia Pac Psychiatry 2015; 7: 173-81.
    Pubmed CrossRef
  16. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 1999; 282:1737-44.
    Pubmed CrossRef
  17. Choi HS, Choi JH, Park KH, Joo KJ, Ga H, Ko HJ, et al. Standardization of the Korean version of Patient Health Questionnaire-9 as a screening instrument for major depressive disorder. J Korean Acad Fam Med 2007; 28: 1149.
  18. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001; 16: 606-13.
    Pubmed KoreaMed CrossRef
  19. Park SJ, Choi HR, Choi JH, Kim K, Hong JP. Reliability and validity of the Patient Health Questionnaire (PHQ-9). Anxiety Mood 2010; 6: 119-24.
  20. The Korean Society of Hypertension. Blood pressure monitoring guidelines [Internet]. Seoul: The Korean Society of Hypertension; 2007 [cited 2012 Jun 8].
    Available from: http://www.koreanhypertension.org/
  21. American Diabetes Association. (2) Classification and diagnosis of diabetes. Diabetes Care 2015; 38(Suppl): S8-16.
    KoreaMed CrossRef
  22. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
    CrossRef
  23. World Health Organization. Regional Office for the Western Pacific (WPRO). The Asia-pacific perspective: redefining obesity and its treatment [Internet]. Melbourne: International Association for the Study of Obesity (IASO), International Obesity TaskForce (IOTF); 2000 [cited 2016 Feb 26].
    Available from: http://www.wpro.who.int/nutrition/documents/docs/Redefiningobesity.pdf
  24. Yan LL, Liu K, Matthews KA, Daviglus ML, Ferguson TF, Kiefe CI. Psychosocial factors and risk of hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. JAMA 2003; 290: 2138-48.
    Pubmed CrossRef
  25. Everson-Rose SA, Meyer PM, Powell LH, Pandey D, Torréns JI, Kravitz HM, et al. Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care 2004; 27: 2856-62.
    Pubmed CrossRef
  26. Vanitallie TB. Stress: a risk factor for serious illness. Metabolism 2002; 51(6 Suppl 1): 40-5.
    Pubmed CrossRef
  27. Ross CE. Overweight and depression. J Health Soc Behav 1994; 35: 63-79.
    Pubmed CrossRef
  28. Istvan J, Zavela K, Weidner G. Body weight and psychological distress in NHANES I. Int J Obes Relat Metab Disord 1992; 16: 999-1003.
    Pubmed

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