Korean J Fam Pract. 2017; 7(3): 382-387  https://doi.org/10.21215/kjfp.2017.7.3.382
Evaluation of Palliative Prognostic Score and Use of Total Parenteral Nutrition for Predicting Survival in Terminally Ill Cancer Patients
Der-Lih Wang, Eun-Jung Kim*, Inseong Kim, Seunggyu Gwon, Donghyeok Park
Department of Family Medicine, Busan Veterans Hospital, Busan, Korea
Eun-Jung Kim
Tel: +82-51-601-6067, Fax: +82-51-601-6339
E-mail: wang6351@naver.com
Received: February 17, 2016; Revised: June 10, 2016; Accepted: July 7, 2016; Published online: June 20, 2017.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Accurate prediction of survival in terminally ill cancer patients is important for planning effective palliative care. The palliative prognostic (PaP) score was designed to predict life expectancy based on clinical symptoms and the clinician’s prediction of survival. The aim of this study was to evaluate the availability of PaP score for determining survival period, the effect of total parenteral nutrition (TPN) on the survival, and the relationship between PaP score and TPN in terminally ill cancer patients in Korea.
Methods: The study involved 61 patients with terminal cancer at one hospital in 2012. The PaP score was constructed with five variables (Karnofsky performance status, anorexia, dyspnea, total white blood cell count, and lymphocyte percentage) and clinical prediction of survival by physicians.
Results: Patients were divided into three groups according to PaP score: group A, ≤5.5; group B, 5.6–11, group C, 11.1–17.5. The 30-day survival probability was 100% for group A, 78.57% for group B, and 0% for group C. A moderate correlation was found between clinician’s predictions and actual survival (correlation coefficient=0.718). TPN had no effect on the survival of terminally ill cancer patients, and there was no significant relationship between TPN use and PaP score.
Conclusion: PaP score was proved to be a reliable tool for predicting survival in terminally ill cancer patients in Korea. It is necessary to establish evidence-based guidelines for use of TPN for these patients.
Keywords: Hospice Care; Survival Analyses; Total Parenteral Nutrition; Hospice
References
  1. Lee IC, Kim CK, Suh SY, Kim YS, Cho KH, Kang HC, et al. Validation of scoring system for survival prediction in terminal cancer patients in Korea. J Korean Acad Fam Med 2007; 28: 682-9.
  2. Lamont EB, Christakis NA. Complexities in prognostication in advanced cancer: “to help them live their lives the way they want to”. JAMA 2003; 290:98-104.
    Pubmed CrossRef
  3. Maltoni M, Nanni O, Pirovano M, Scarpi E, Indelli M, Martini C, et al. Successful validation of the palliative prognostic score in terminally ill cancer patients. Italian Multicenter Study Group on Palliative Care. J Pain Symptom Manage 1999; 17: 240-7.
    CrossRef
  4. Morita T, Tsunoda J, Inoue S, Chihara S. The Palliative Prognostic Index: a scoring system for survival prediction of terminally ill cancer patients. Support Care Cancer 1999; 7: 128-33.
    Pubmed CrossRef
  5. Son HR, Kim DE, Kang HW, Kim HN, Seo IK, Yoon JY, et al. Survival prediction in terminally ill cancer patients: laboratory variables and prospective validation of the palliative prognostic index. Korean J Med 2011; 81: 359-65.
  6. Brennan MF, Pisters PW, Posner M, Quesada O, Shike M. A prospective randomized trial of total parenteral nutrition after major pancreatic resection for malignancy. Ann Surg 1994; 220: 436-41; discussion 441-4.
    Pubmed KoreaMed CrossRef
  7. Fan ST, Lo CM, Lai EC, Chu KM, Liu CL, Wong J. Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma. N Engl J Med 1994; 331: 1547-52.
    Pubmed CrossRef
  8. Kim DY, Lee SM, Lee KE, Lee HR, Kim JH, Lee KW, et al. An evaluation of nutrition support for terminal cancer patients at teaching hospitals in Korea. Cancer Res Treat 2006; 38: 214-7.
    Pubmed KoreaMed CrossRef
  9. Glare P, Virik K, Jones M, Hudson M, Eychmuller S, Simes J, et al. A systematic review of physicians’ survival predictions in terminally ill cancer patients. BMJ 2003; 327: 195-8.
    Pubmed KoreaMed CrossRef
  10. Suh SY, Choi YS, Shim JY, Kim YS, Yeom CH, Kim D, et al. Construction of a new, objective prognostic score for terminally ill cancer patients: a multicenter study. Support Care Cancer 2010; 18: 151-7.
    Pubmed CrossRef
  11. Cha YY, Jung TK, Lim SC. Evaluation of nutritional improvement by total parenteral nutrition guideline in early malnourished inpatients. Korean J Clin Pharm 2013; 23: 365-72.


This Article

e-submission

Archives