Korean J Fam Pract. 2017; 7(6): 807-811  https://doi.org/10.21215/kjfp.2017.7.6.807
The Association between Triglyceride to High Density Lipoprotein Cholesterol Ratio and Intraocular Pressure
Ji-Hye Kim1,2, Ah-Rana Kim1,2, Dong-Hyuk Jung1,2,*
1Department of Family Medicine, Gangnam Severance Hospital, Seoul; 2Department of Family Medicine, Yongin Severance Hospital, Yongin, Korea
Dong-Hyuk Jung
Tel: +82-31-331-8821, Fax: +82-31-331-8709
E-mail: balsan2@yuhs.ac
Received: February 28, 2017; Revised: August 18, 2017; Accepted: August 28, 2017; Published online: December 20, 2017.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: An elevated intraocular pressure (IOP) is shown to be associated with cardiometabolic risk factors such as age, sex, hypertension, diabetes mellitus, obesity and metabolic syndrome. The triglyceride (TG) to high density lipoprotein cholesterol (HDL-C) ratio has also been demonstrated to show a strong association with cardiometabolic disease. We aimed to investigate the association between IOP and the TG:HDL-C ratio in Koreans without glaucoma.
Methods: We performed a cross-sectional study involving 7,244 participants who enrolled in a health examination program at the Gangnam Severance Hospital in Korea. Patients were divided into 4 equal groups based on the TG/HDL-C ratio and 2 groups based on IOP values with the difference between groups being 15 mmHg. Multiple logistic regression analysis was used to assess the relationship between a high IOP and the TG/HDL-C ratio after adjusting for age, sex, and total serum cholesterol values.
Results: A significant relationship was observed between IOP and the TG/HDL-C ratio, and the mean IOP gradually increased in accordance with the quartile of the TG/HDL-C ratio (P<0.001). Multiple regression analysis showed that a high IOP was significantly associated with the highest quartile of the TG/HDL-C ratio after adjusting for age, sex, and total serum cholesterol (95% confidence interval, 1.098–1.545; P<0.01).
Conclusion: A high TG/HDL-C ratio was independently associated with an elevated IOP in Koreans without glaucoma.
Keywords: Triglycerides; High Density Lipoprotein-Cholesterol; Intraocular Pressure; South Korea
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