Korean J Fam Pract. 2018; 8(1): 39-46  https://doi.org/10.21215/kjfp.2018.8.1.39
Association of Metabolic Factors with Prostate Volume and Prostate-Specific Antigen
Taek-Young Kim, Da-Hye Choi*, Tae-Young Lee, Hyun-Chul Moon, Young-In An, Seong-Jee Park, Myung-Chul Jung
Department of Family Medicine, Daejeon Veterans Hospital, Daejeon, Korea
Da-Hye Choi
Tel: +82-42-939-0314, Fax: +82-42-939-0567
E-mail: dahye76@bohun.or.kr
ORCID: http://orcid.org/0000-0002-0522-982X
Received: March 9, 2017; Revised: August 31, 2017; Accepted: September 3, 2017; Published online: February 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: This study was undertaken to evaluate the association of metabolic factors with prostate volume and prostate specific antigen in Korean adult men.
Methods: From January 2011 to December 2015, 268 male patients in a Daejeon Veterans Hospital were enrolled in a retrospective study. Exceptions were patients who were diagnosed with prostate-related diseases such as benign prostatic hyperplasia, prostatitis, or prostate cancer. The association of the results of anthropometric measurements of height, weight, waist circumference, body mass index (BMI), systolic and diastolic blood pressure, and blood chemistry values for fasting blood glucose, total cholesterol, high density lipoprotein, low density lipoprotein, triglyceride, aspartate transaminase, alanine transaminase and gamma-glutamyl transferase with prostate volume and prostate-specific antigen were analyzed by independent-samples t-test, Pearson correlation test, and multiple linear regression analysis. We also analyzed the relationship between metabolic syndrome and the prostate volume and prostate-specific antigen, and in reverse we analyzed the relationship between prostate volume and prostate-specific antigen on metabolic syndrome.
Results: Prostate volume was significantly increased with waist circumference and fasting blood glucose. In addition, as the BMI increased, the prostate-specific antigen level decreased statistically. However, the prevalence of metabolic syndrome, and prostate volume and prostate-specific antigen levels were not found to be statistically significant.
Conclusion: In Korean adult men, waist circumference (P＜0.05) and fasting blood glucose (regression coefficient [β]±standard errors [SE]=0.051±0.018, P＜0.01) have a positive correlation with prostate volume, and body mass index and prostate-specific antigen have a negative correlation (β±SE=-0.059±0.019, P＜0.01).
Keywords: Prostate; Prostate-Specific Antigen; Waist Circumference; Blood Glucose; Body Mass Index; Metabolic Syndrome
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