Korean J Fam Pract. 2018; 8(1): 80-86  https://doi.org/10.21215/kjfp.2018.8.1.80
Relationship between Body Mass Index and Microalbuminuria in Healthy Adults
Min-hee Seo1, Youngmin Jee1, Byung-Wook Yoo1,*, Sung-ho Hong1, Choo-yon Cho1, Yong-jin Cho2, Jung-eun Oh2, Kyung-Suk Shin3, Hyun Joe1, Hwang-sik Shin2, Doo-yong Son3
1Department of Family Medicine, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul; 2Department of Family Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan; 3Department of Family Medicine, Gumi Hospital, Soonchunhyang University College of Medicine, Gumi, Korea
Byung-Wook Yoo
Tel: +82-2-709-9458, Fax: +82-2-795-3687
E-mail: dryoo@schmc.ac.kr
ORCID: http://orcid.org/0000-0002-8753-9660
Received: March 13, 2017; Revised: June 20, 2017; Accepted: June 30, 2017; Published online: February 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The worldwide incidence rates of obesity and overweight has rapidly increased among both men and women over the past few decades. These can be associated with increased risks for many health problems such as heart disease, stroke, high blood pressure, and aggravation of diabetes mellitus. Thus, preliminary identification plays a critical role in preventing and reducing serious illnesses and diseases related to obesity. We aimed to evaluate the prevalence of microalbuminuria according to body mass index and its relationship with obesity and chronic renal disease.
Methods: We analyzed data from the 2011–2013 Korea National Health and Nutrition Examination Survey. Our study included 3,564 men and 3,967 women without hypertension, diabetes mellitus, chronic liver disease, chronic kidney disease, or cancer. Body mass indexes (BMIs) were categorized as follows: <23.0 kg/m2, 23.0–24.9 kg/m2, and ≥25.0 kg/m2. Microalbuminuria was defined as a urinary albumin-to-creatinine ratio <30 mg/g.
Results: On the basis of the results of binary logistic regression analysis, we found that the odds ratios (ORs) for microalbuminuria in the obesity group were relatively higher: 1.672 for men (95% confidence interval [CI], 1.087–2.570) and 2.057 for women (95% CI, 1.417–2.987), after adjustment for age, alcohol consumption, smoking, and physical activity.
Conclusion: The prevalence of microalbuminuria in the obese population was increased. The ORs clearly imply that the BMI values are strongly associated with the risk for renal function decrement. Therefore, regular screening is recommended for obese individuals.
Keywords: Body Mass Index; Obesity; Microalbuminuria; Renal Function
References
  1. Arroyo-Johnson C, Mincey KD. Obesity epidemiology worldwide. Gastroenterol Clin North Am 2016; 45: 571-9.
    Pubmed KoreaMed CrossRef
  2. Eckel RH, Barouch WW, Ershow AG. Report of the national heart, lung, and blood institute-national institute of diabetes and digestive and kidney diseases working group on the pathophysiology of obesity-associated cardiovascular disease. Circulation 2002; 105: 2923-8.
    Pubmed CrossRef
  3. Navarro-Díaz M, Serra A, Romero R, Bonet J, Bayés B, Homs M, et al. Effect of drastic weight loss after bariatric surgery on renal parameters in extremely obese patients: long-term follow-up. J Am Soc Nephrol 2006; 17(12 Suppl 3): S213-7.
    Pubmed CrossRef
  4. Hall ME, do Carmo JM, da Silva AA, Juncos LA, Wang Z, Hall JE. Obesity, hypertension, and chronic kidney disease. Int J Nephrol Renovasc Dis 2014;7: 75-88.
    Pubmed KoreaMed CrossRef
  5. Iseki K, Ikemiya Y, Kinjo K, Inoue T, Iseki C, Takishita S. Body mass index and the risk of development of end-stage renal disease in a screened cohort. Kidney Int 2004; 65: 1870-6.
    Pubmed CrossRef
  6. Tozawa M, Iseki K, Iseki C, Oshiro S, Ikemiya Y, Takishita S. Influence of smoking and obesity on the development of proteinuria. Kidney Int 2002;62: 956-62.
    Pubmed CrossRef
  7. Lu JL, Kalantar-Zadeh K, Ma JZ, Quarles LD, Kovesdy CP. Association of body mass index with outcomes in patients with CKD. J Am Soc Nephrol 2014; 25: 2088-96.
    Pubmed KoreaMed CrossRef
  8. Hsu CY, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med 2006; 144: 21-8.
    Pubmed CrossRef
  9. Kim DK, Joo KW. Definition and evaluation of acute kidney injury: clinical practice guidelines. Korean J Med 2015; 88: 357-62.
    CrossRef
  10. Trevisan R, Dodesini AR, Lepore G. Lipids and renal disease. J Am Soc Nephrol 2006; 17(4 Suppl 2): S145-7.
    Pubmed CrossRef
  11. American Diabetes Association. Executive summary: standards of medical care in diabetes--2012. Diabetes Care 2012; 35 Suppl 1: S4-10.
    Pubmed KoreaMed CrossRef
  12. Gerstein HC, Mann JF, Yi Q, Zinman B, Dinneen SF, Hoogwerf B, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 2001; 286: 421-6.
    Pubmed CrossRef
  13. Iliescu R, Chade AR. Progressive renal vascular proliferation and injury in obese Zucker rats. Microcirculation 2010; 17: 250-8.
    Pubmed KoreaMed CrossRef
  14. Zhang X, Lerman LO. Obesity and renovascular disease. Am J Physiol Renal Physiol 2015; 309: F273-9.
    Pubmed KoreaMed CrossRef
  15. Ferris M, Hogan SL, Chin H, Shoham DA, Gipson DS, Gibson K, et al. Obesity, albuminuria, and urinalysis findings in US young adults from the Add Health Wave III study. Clin J Am Soc Nephrol 2007; 2: 1207-14.
    Pubmed CrossRef
  16. Naumnik B, Myśliwiec M. Renal consequences of obesity. Med Sci Monit 2010; 16: RA163-70.
    Pubmed


This Article


Author ORCID Information

Services
Social Network Service

e-submission

Archives