Korean J Fam Pract. 2018; 8(2): 201-206  https://doi.org/10.21215/kjfp.2018.8.2.201
The Association between Obesity and Gastric Ulcer in Korean Adult
Youngjung Kim, Eun-Ki Kim*, Ho-joon Lee, jonghwa Kuk, Joo-Hwa Park, Jun Ko, Joungyoun Kim, Bo-Mi Jeong
Department of Family Medicine, Hankook General Hospital, Cheongju, Korea
Eun-Ki Kim
Tel: +82-43-222-7000, Fax: +82-43-255-7007
E-mail: keunk7268@hanmail.net
ORCID: http://orcid.org/0000-0001-9100-9905
Received: March 31, 2017; Revised: October 10, 2017; Accepted: October 19, 2017; Published online: April 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Many studies have been conducted on the association between esophagogastroduodenoscopy (EGD) findings and obesity. However, no reports have indicated that obesity, diagnosed in accordance with the Korean Society for the Study of Obesity criteria, could be associated with gastric ulcer. Therefore, we investigated the relationship between obesity and gastric ulcer.
Methods: We collected data from 3,901 subjects who underwent EGD among the patients who visited a Korean general hospital between January 2014 and May 2014 for medical examination. All the subjects were surveyed for age, sex, smoking habit, and standard physical measurements, such as body mass index (BMI), resting blood pressure, waist measurement, and estimated fasting blood glucose and serum lipid levels, and underwent gastroendoscopic examination. BMI was classified into two groups (BMI of 25 kg/m2 or waist measurement of >90 cm for men and >85 cm for women and BMI of <25 kg/m2, obese or normal). The study subjects were classified into two groups according to EGD findings (normal or gastric ulcer).
Results: Of the 3,901 subjects, 89 had gastric ulcer while 3,801 did not. The obese group consisted of 1,234 subjects; and the normal group, 2,667 subjects. In comparison to the normal group, in the gastric ulcer group, the proportions of male and obese subjects, mean age, and diastolic blood pressure (BP) were higher and mean high-density lipoprotein level was lower. After adjusting for age, sex, smoking habit, fasting glucose level, resting BP, and serum lipid levels, gastric ulcer risk was not significantly higher in the obese group than in the normal weight group.
Conclusion: Obesity was not related to gastric ulcer.
Keywords: Gastric Ulcer; Obesity; Body Mass Index; Esophagogastroduodenoscopy
References
  1. Finkelstein EA, Khavjou OA, Thompson H, Trogdon JG, Pan L, Sherry B, et al. Obesity and severe obesity forecasts through 2030. Am J Prev Med 2012;42: 563-70.
    Pubmed CrossRef
  2. Kim HJ, Yoo TW, Park DI, Park JH, Cho YK, Sohn CI, et al. Influence of overweight and obesity on upper endoscopic findings. J Gastroenterol Hepatol 2007; 22: 477-81.
    Pubmed CrossRef
  3. El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol 2005; 100: 1243-50.
    Pubmed CrossRef
  4. Lee SH. Gastric ulcer and ulcerative gastric cancer. Clin Endosc 2015; 48:553-7.
  5. Choi MH. The endoscopic diagnosis of peptic ulcer disease. Korean J Helicobacter Up Gastrointest Res 2014; 14: 6-12.
    CrossRef
  6. Aro P, Ronkainen J, Talley NJ, Storskrubb T, Bolling-Sternevald E, Agréus L. Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based study. Gut 2005; 54: 1377-83.
    Pubmed KoreaMed CrossRef
  7. Jang Y, Lee K, Jung S. The association between esophagogastroduodenoscopic findings and the related risk factors of obesity. Korean J Fam Med 2010; 31: 44-50.
    CrossRef
  8. Kim SG, Kim JG, Shin SK, Kim HS, Seol SY. Guidelines of diagnosis for peptic ulcer disease. Korean J Gastroenterol 2009; 54: 279-84.
    Pubmed CrossRef
  9. Lee SH, Lee DJ, Kim KM, Park SB, Kim BT, Joo NS, et al. Diagnosis and management of peptic ulcer disease. Korean J Fam Pract 2013; 3: 395-405.
  10. Korman MG, Hansky J, Eaves ER, Schmidt GT. Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology 1983; 85: 871-4.
    Pubmed
  11. Friedman GD, Siegelaub AB, Seltzer CC. Cigarettes, alcohol, coffee and peptic ulcer. N Engl J Med 1974; 290: 469-73.
    Pubmed CrossRef
  12. Salga MS, Ali HM, Abdulla MA, Abdelwahab SI. Gastroprotective activity and mechanism of novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino) ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration. Chem Biol Interact 2012; 195: 144-53.
    Pubmed CrossRef
  13. Li NS, Luo XJ, Zhang YS, He L, Liu YZ, Peng J. Phloroglucinol protects gastric mucosa against ethanol-induced injury through regulating myeloperoxidase and catalase activities. Fundam Clin Pharmacol 2011; 25: 462-8.
    Pubmed CrossRef
  14. Fu XC, Shan HL, Bai HB, Hu R. Protective effect of Jiangbaiweiyan tablet on ethanol-induced gastric mucosa injury in rats. Zhejiang Da Xue Xue Bao Yi Xue Ban 2011; 40: 391-4.
    Pubmed
  15. Feldman M, Walker P, Green JL, Weingarden K. Life events stress and psychosocial factors in men with peptic ulcer disease. A multidimensional casecontrolled study. Gastroenterology 1986; 91: 1370-9.
    CrossRef
  16. Hui WM, Shiu LP, Lok AS, Lam SK. Life events and daily stress in duodenal ulcer disease. A prospective study of patients with active disease and in remission. Digestion 1992; 52: 165-72.
    Pubmed CrossRef
  17. Klein S, Wadden T, Sugerman HJ. AGA technical review on obesity. Gastroenterology 2002; 123: 882-932.
    Pubmed CrossRef
  18. Talley NJ, Howell S, Poulton R. Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study. Am J Gastroenterol 2004;99: 1807-14.
    Pubmed CrossRef
  19. Kamal N, Chami T, Andersen A, Rosell FA, Schuster MM, Whitehead WE. Delayed gastrointestinal transit times in anorexia nervosa and bulimia nervosa. Gastroenterology 1991; 101: 1320-4.
    CrossRef
  20. Robinson PH, Clarke M, Barrett J. Determinants of delayed gastric emptying in anorexia nervosa and bulimia nervosa. Gut 1988; 29: 458-64.
    Pubmed KoreaMed CrossRef
  21. Lee BI. Role of Gastroenterologists in management of obesity. Korean J Gastroenterol 2015; 66: 186-9.
    Pubmed CrossRef


This Article


Author ORCID Information

Services
Social Network Service

e-submission

Archives