Korean J Fam Pract. 2018; 8(3): 372-379  https://doi.org/10.21215/kjfp.2018.8.3.372
Interdependency of Risk Factors for Hypertension: The 2010–2015 Korean National Health and Nutrition Examination Survey
Hyun Ryung Nam1, Serng Bai Pak2,*, Suk Joon Jung 3,*, In Young Choi1, Yesul Kim2
1Department of Family Medicine, Severance Hospital, Seoul; 2Department of Family Medicine, National Health Insurance Service Ilsan Hospital, Goyang; 3Department of New Biology, DGIST, Daegu, Korea
Serng Bai Pak
Tel: +82-31-900-0440, Fax: +82-31-900-0343
E-mail: aledma11@nhimc.or.kr
ORCID: http://orcid.org/0000-0001-8939-8737
Suk Joon Jung
Tel: +82-53-785-1942, Fax: +82-6008-1458
E-mail: jsj0719@dgist.ac.kr
ORCID: http://orcid.org/0000-0003-3509-3131
Received: May 11, 2017; Revised: October 20, 2017; Accepted: October 24, 2017; Published online: June 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Identifying the risk factors for hypertension and predicting the likelihood of developing it is important for efficient distribution of limited health resources and for improving public health. Age, sex, family history, and obesity are the known risk factors for onset of essential hypertension. However, results of studies on the significance of some risk factors are not consistent. If the relationship is nonlinear or dependent on other variables, variable outcomes may be derived, depending on group selection. To overcome these problems, we investigated the interdependence among the 10 risk factors of hypertension and analyzed the significance interdependency by network of the 10 risk factors has been constructed and analyzed to overcome the problem.
Methods: We integrated the data of the 5th and 6th National Health and Nutrition Examination Survey to generate a comprehensive database for 23,980 adults aged 30 years or older. Each risk factor was divided into two groups, and the dependencies between the risk factors were modeled. To exclude group biases and secondary associations, the sample was divided into 128 groups based on 8 risk factors, other than variables that examined dependency, and weights were given. The significance was confirmed by making a distribution of 100,000 random mixtures of the variables, and the dependence relation between the risk factors estimated through the model was analyzed.
Results: We confirmed a relationship between the risk factors of hypertension. Of the 10 risk factors used in the study, 9 were identified in a close network of obesity.
Conclusion: There is a complex interdependence between the risk factors of hypertension, which varies according to the risk factors.
Keywords: Hypertension; Multivariate Analysis; Risk Factors; Alcohol; Smoking
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