Korean J Fam Pract. 2018; 8(3): 462-467  https://doi.org/10.21215/kjfp.2018.8.3.462
Relationship between the Ratio of Triglyceride to High Density Lipoprotein and Glycated Hemoglobin A in 4-5 Years Follow-up in Non-Diabetic Adults
Hyun-Ha Kim, Woo-Joo Park, Soo-Eun Jang, Seung-Ryong Yoo, Hyeona-A Lee, Mi-Kyeong Oh*
Department of Family Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea
Mi-Kyeong Oh
Tel: +82-33-610-3325, Fax: +82-33-641-8130
E-mail: omk@gnah.co.kr
ORCID: http://orcid.org/0000-0003-3602-9588
Received: June 13, 2017; Revised: August 18, 2017; Accepted: August 28, 2017; Published online: June 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: There is growing interest in factors that can predict the occurrence of diabetes. Several studies have reported that the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C ratio) reflects insulin resistance. The present study investigated whether the TG/HDL-C ratio can be a predictor of diabetes mellitus, considering that insulin resistance is an important mechanism for the risk of diabetes mellitus.
Methods: Among 1,177 patients who underwent two or more tests at 4- or 5-year intervals from 2006 to 2016 at a hospital health examination center in Gangwon-do Province, except for patients with chronic illnesses affecting the quality of data and lipid levels, 817 patients were included in the study. High TG/HDL-C ratios were based on previous studies: 3.5 for men and 2.0 for women. We investigated the relationship between the TG/HDL-C ratio and glycated hemoglobin A (HbA1c) levels, and we examined whether the first TG/HDL-C ratio was related to changes in HbA1c levels and the presence or absence of diabetes after 4–5 years.
Results: Simultaneously, the high TG/HDL-C ratio group had significantly higher mean HbA1c levels. In men, the high TG/HDL-C ratio group showed a tendency of increased HbA1c levels 4–5 years later (P=0.060). In logistic regression analysis, the TG/HDL-C ratio did not show a significant relationship with the incidence of diabetes after 4–5 years.
Conclusion: Although the TG/HDL-C ratio is closely related to HbA1c levels, this study did not predict the increase in HbA1c levels and the occurrence of diabetes after 4–5 years.
Keywords: Triglycerides; Lipoprotein HDL; Glycated Hemoglobin A ; Diabetes Mellitus; Insulin Resistance
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