Korean J Fam Pract. 2018; 8(4): 518-523  https://doi.org/10.21215/kjfp.2018.8.4.518
The Association between Serum 25-hydroxyvitamin D Levels, Fasting Glucose, and Hemoglobin A1c in Nondiabetic Adults: Based on the Korea National Health and Nutrition Examination Survey, 2013-2014
Hye Mi Lee1, Tai Chi Lin1, Joon Suk Oh1, Han Na Seo1, Hye Rim Kong2, Sung A Cho2, Bong Gyu Choi1,*
1Department of Family Medicine, Gwangmyeong Sungae Hospital, Gwangmyeong; 2Department of Family Medicine, Sungae Hospital, Seoul, Korea
Bong Gyu Choi Tel: +82-31-442-7208, Fax: +82-2-897-2225 E-mail: stapy74@hanmail.net ORCID: http://orcid.org/0000-0002-3721-4913
Received: June 23, 2017; Revised: August 30, 2017; Accepted: September 6, 2017; Published online: August 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Vitamin D is important in the metabolism of minerals and bones, and it is also known to influence an effect on diseases such as cardiovascular disease, autoimmune disease, and diabetes. It has been proven that it correlates with the development of glucose metabolism and diabetes. The aim of this study was to investigate the association between serum vitamin D levels, fasting glucose, and glycated hemoglobin (HbA1c) in nondiabetic adults.
Methods: Of the nondiabetic adults who participated in the National Health and Nutrition Examination Surveys from 2013 and 2014, serum 25-hydroxyvitamin D (25[OH]D) levels were measured. The participants were divided into three groups, and their fasting glucose and HbA1c levels were analyzed.
Results: The results of the analysis of the three groups revealed that higher serum 25(OH)D levels were associated with higher fasting glucose and HbA1c levels (P<0.05). In a multiple logistic regression analysis, the risk degree of serum 25(OH)D deficiency increased in fasting glucose (P<0.05) after adjustment for various factors.
Conclusion:. In this study, higher serum 25(OH)D levels were associated with higher fasting glucose and HbA1c levels. The risk degree of serum 25(OH)D deficiency increased in fasting glucose after adjustments for various factors. The results are different from those of previous studies, but a statistical correlation was found; therefore, further study is required to prove a definite correlation.
Keywords: Vitamin D; Fasting Glucose; Glycated Hemoglobin A; Diabetes Mellitus
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