Korean J Fam Pract. 2018; 8(5): 703-708  https://doi.org/10.21215/kjfp.2018.8.5.703
Risk Factors of Gallbladder Polyp, and Association between Gallbladder Polyp and Dyslipidemia in Health Examines
Kwang Wook Jung, Ah Ra Koh, Chun Hwan Kim, Jun Ho Bang, Jung Hwan Lee*
Department of Family Medicine, Dongsuwon Medical Center, Suwon, Korea
Jung Hwan Lee
Tel: +82-31-210-0114, Fax: +82-31-211-5145
E-mail: kwjmd11@naver.com
ORCID: http://orcid.org/0000-0001-7090-4257
Received: July 20, 2017; Revised: October 18, 2017; Accepted: October 19, 2017; Published online: October 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Gallbladder polyps may be a cause of gallbladder cancer. The known risk factors for gallbladder polyps include male sex, obesity, metabolic syndrome, and hepatitis B surface antigen positivity. However, previous studies on the relationship between blood lipid levels and gallbladder polyps have been unclear. We evaluated risk factors for gallbladder polyps and the association between dyslipidemia and gallbladder polyps.
Methods: From January 2011 to December 2014, 6,865 individuals who visited a health checkup center, Dongsuwon Hospital in Suwon were examined for height, body weight, blood pressure, blood chemistry, and lipid profile. We also performed abdominal ultrasonography to identify gallbladder polyps. The risk factors for gallbladder polyps were analyzed by multivariate analysis.
Results: The prevalence of gallbladder polyps was 3.3% (227/6,865). There were more men and more obese patients (body max index ≥25 kg/m2) in the gallbladder polyp group than in the non-gallbladder polyp group. Moreover, height, body weight, total cholesterol, and low density lipoprotein (LDL) cholesterol were statistically higher in the gallbladder polyp group than in the non-gallbladder polyp group. In the multivariate analysis, male sex (odd ratio [OR] 2.198), obesity (OR 1.378), and LDL cholesterol (OR 1.007) were risk factors for gallbladder polyps. In the univariate analysis, patients with LDL cholesterol level ＞130 mg/dL had a 1.7-times (OR 1.778) higher risk of developing gallbladder polyps than those with LDL cholesterol level ＜130 mg/dL.
Conclusion: The risk factors for gallbladder polyps were male sex, obesity, and high LDL cholesterol. Triglyceride and high density cholesterol levels were not associated with the presence of gallbladder polyps.
Keywords: Gallbladder Disease; Hypercholesterolemia; Obesity; Male
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