Korean J Fam Pract. 2018; 8(5): 778-782  https://doi.org/10.21215/kjfp.2018.8.5.778
Relationship between the Degree of Blood Pressure Control and Intima-Media Thickness or Atherosclerosis in Patients with Acute Cerebral Infarction
Dong Su Kang, Hyo Rim Son*, Eui Won Kim, Da Mi You, Doo Wan Cho
Department of Family Medicine, Gwangju Veterans Hospital, Gwangju, Korea
Hyo Rim Son
Tel: +82-62-602-6015, Fax: +82-62-602-6983
E-mail: dfms3242@hanmail.net
ORCID: http://orcid.org/0000-0003-2239-1914
Received: May 31, 2017; Revised: October 10, 2017; Accepted: October 19, 2017; Published online: October 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Carotid intima-media thickness (IMT) is a predictor of cerebral infarction. The incidence of cerebral infarction increases as atherosclerotic plaque size and external carotid artery stenosis progress.
Methods: Subjects were classified according to the degree of blood pressure control and carotid IMT was measured. The t-test and analysis of variance and Scheffe’s post-hoc test were used to determine differences in IMT according to the degree of blood pressure control. Crossover analysis with the chi-square test was used to evaluate differences in IMT and atherosclerotic plaque according to the degree of blood pressure control.
Results: There was no statistical association between the degree of blood pressure control and IMT, with a significance level of 0.290. There was no statistical association between the degree of blood pressure control and abnormal IMT, with a significance level of 0.224. There was no statistical association between the degree of blood pressure control and the presence of atherosclerotic plaque, with a significance level of 0.370.
Conclusion: The mean carotid IMT did not show a statistically significant difference, even when blood pressure was increased. The distribution of abnormal did not increase even if blood pressure control was improved. The presence of atherosclerotic plaque was not significantly associated with the degree of blood pressure control.
Keywords: Carotid Intima-Media Thicnkness; Brain Infarction; Ultrasonography; Atherosclerosis; Hypertension
References
  1. Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002; 20: 159-69.
    Pubmed CrossRef
  2. Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, et al. Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation 2000; 101: E16-22.
    Pubmed CrossRef
  3. Bots ML, Evans GW, Riley WA, Grobbee DE. Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view. Stroke 2003; 34: 298594.
    Pubmed CrossRef
  4. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol 1997; 146: 483-94.
    Pubmed CrossRef
  5. Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med 1994; 236: 567-73.
    CrossRef
  6. Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002; 20: 159-69.
    Pubmed CrossRef
  7. Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 1998; 128: 262-9.
    Pubmed CrossRef
  8. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1997; 340: 14-22.
    Pubmed CrossRef
  9. Aminbakhsh A, Frohilich J, Mancini GB. Detection of early atherosclerosis with B mode carotid ultrasonography: assessment of a new quantitative approach. Clin Invest Med 1999; 22: 265-74.
    Pubmed
  10. Handa N, Mastumoto M, Maeda H, Hougaku H, Itoh T, Okazaki Y, et al. [An ultrasonic study of the relationship between extracranial carotid atherosclerosis and ischemic cerebrovascular disease in Japanese]. Nihon Ronen Igakkai Zasshi 1992; 29: 742-7. Japanese.
    Pubmed CrossRef
  11. Whitworth JA; World Health Organization, International Society of Hypertension Writing Group. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003; 21: 1983-92.
    Pubmed CrossRef
  12. Adams MR, Celermajer DS. Detection of presymptomatic atherosclerosis: a current perspective. Clin Sci (Lond) 1999; 97: 615-24.
    CrossRef
  13. Nappo F, De Rosa N, Marfella R, De Lucia D, Ingrosso D, Perna AF, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA 1999; 281: 2113-8.
    Pubmed CrossRef
  14. Ebrahim S, Papacosta O, Whincup P, Wannamethee G, Walker M, Nicolaides AN, et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke 1999; 30: 841-50.
    Pubmed CrossRef
  15. Lee JJ, Hong JY, Jung YH, Choi JH, Lee SI, Cha MJ, et al. Usefulness of carotid plaque and intima-media thickness measurement in patients with acute ischemic stroke. J Neurosonology 2010; 2: 19-26.
  16. Friedman MH, Deters OJ, Bargeron CB, Hutchins GM, Mark FF. Shear-dependent thickening of the human arterial intima. Atherosclerosis 1986; 60:161-71.
    CrossRef
  17. Friedman MH, Bargeron CB, Deters OJ, Hutchins GM, Mark FF. Correlation between wall shear and intimal thickness at a coronary artery branch. Atherosclerosis 1987; 68: 27-33.
    CrossRef
  18. Lee JS, Shin YJ, Jeong SK. Preliminary study on the topological characteristics of carotid intima-media thickness in hypertensives. J Korean Neurol Assoc 2007; 25: 57-63.

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