Korean J Fam Pract. 2018; 8(6): 890-895  https://doi.org/10.21215/kjfp.2018.8.6.890
Effects of Knee Osteoarthritis on Lower Extremity Sarcopenia and Quality of Life in Korean Elderly
Jeong Hwa Heo1, Jeong Jae Moon2,*, Seung Min Ryu2, Noh Cheol Park1, Moon Young Kang1
1Department of Family Medicine, Keimyung University Dongsan Hospital; 2Department of Orthopedic Surgery, Yeungnam University Hospital, Daegu, Korea
Jeong Jae Moon
Tel: +82-53-620-3640, Fax: +82-53-628-4020
E-mail: dreamjj21c@naver.com
ORCID: http://orcid.org/0000-0002-4837-8753
Received: December 4, 2017; Revised: June 22, 2018; Accepted: August 6, 2018; Published online: December 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Diagnosis of sarcopenia using lower extremity skeletal muscle mass may be useful. This study investigated the relationship between knee osteoarthritis and the prevalence of sarcopenia using lower limb skeletal muscle mass, and the relationship between sarcopenia symptoms and quality of life in knee osteoarthritis.
Methods: We used the 5th Korea National Health and Nutrition Examination Survey data, 2010. The data for 927 Koreans aged ≥65 years were crosssectionally analyzed. Sarcopenia was diagnosed by calculating the lower skeletal muscle index from muscle mass measured using dual energy X-ray absorptiometry. Knee osteoarthritis, clinical symptoms (pain & stiffness), and quality of life were evaluated.
Results: Based on lower extremity skeletal muscle mass, the prevalence of sarcopenia was 9.9% in patients with radiographic knee osteoarthritis, and 9.3% in patients without osteoarthritis. Diagnosis of sarcopenia based on lower extremity skeletal muscle mass showed a significant correlation with clinical symptoms of osteoarthritis and quality of life.
Conclusion: There was no correlation between the presence of knee osteoarthritis and the prevalence of sarcopenia. However, the diagnosis of sarcopenia based on lower extremity skeletal muscle mass is valuable for determining treatment of knee pain and improving quality of life.
Keywords: Sarcopenia; Osteoarthritis; Lower Extremity Skeletal Muscle Mass Index; Quality of Life
References
  1. Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, et al. Osteoarthritis. Lancet 2015; 386: 376-87.
    CrossRef
  2. Bronson W, Strauss E, Bronson M. Osteoarthritis: eliminating pain and restoring function: an orthopedic perspective. Clin Geriatr 2010; 18: 9-10.
  3. Vennu V, Bindawas SM. Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study. Clin Interv Aging 2014; 9: 793-800.
    Pubmed KoreaMed CrossRef
  4. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 2010;39: 412-23.
    Pubmed KoreaMed CrossRef
  5. Kemmler W, Teschler M, Goisser S, Bebenek M, von Stengel S, Bollheimer LC, et al. Prevalence of sarcopenia in Germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FORMoSA study. Clin Interv Aging 2015; 10: 1565-73.
    Pubmed KoreaMed CrossRef
  6. Scott D, Blizzard L, Fell J, Jones G. Prospective study of self-reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in communitydwelling older adults. Arthritis Care Res (Hoboken) 2012; 64: 30-7.
    Pubmed CrossRef
  7. Bennell KL, Wrigley TV, Hunt MA, Lim BW, Hinman RS. Update on the role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am 2013; 39: 145-76.
    Pubmed CrossRef
  8. Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 2014; 15: 95-101.
    Pubmed CrossRef
  9. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957; 16: 494-502.
    CrossRef
  10. Szende A, Oppe M, Devlin NJ. EQ-5D value sets : inventory, comparative review and user guide. Dordrecht: Springer Science & Business Media;2007.
    CrossRef
  11. Lim NY, Lee IO, Lee EN, Lee KS, Cho KS, Rhee SJ, et al. A validation study of EQ-5D in the patients with osteoarthritis. J Muscle Joint Health 2010; 17:203-11.
    CrossRef
  12. Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998; 147: 755-63.
    Pubmed CrossRef
  13. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002; 50: 889-96.
    Pubmed CrossRef
  14. Lim S, Kim JH, Yoon JW, Kang SM, Choi SH, Park YJ, et al. Sarcopenic obesity:prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA). Diabetes Care 2010;33: 1652-4.
    Pubmed KoreaMed CrossRef
  15. Moon JJ, Park SG, Ryu SM, Park CH. New skeletal muscle mass index in diagnosis of sarcopenia. J Bone Metab 2018; 25: 15-21.
    Pubmed KoreaMed CrossRef
  16. Lang CH, Frost RA, Nairn AC, MacLean DA, Vary TC. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab 2002; 282: E336-47.
    Pubmed CrossRef
  17. Morley JE, Abbatecola AM, Argiles JM, Baracos V, Bauer J, Bhasin S, et al. Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 2011; 12: 403-9.
    Pubmed KoreaMed CrossRef
  18. Papalia R, Zampogna B, Torre G, Lanotte A, Vasta S, Albo E, et al. Sarcopenia and its relationship with osteoarthritis: risk factor or direct consequence? Musculoskelet Surg 2014; 98: 9-14.
    Pubmed CrossRef
  19. Cooper C, Fielding R, Visser M, van Loon LJ, Rolland Y, Orwoll E, et al. Tools in the assessment of sarcopenia. Calcif Tissue Int 2013; 93: 201-10.
    Pubmed KoreaMed CrossRef
  20. Marzetti E, Lees HA, Manini TM, Buford TW, Aranda JM Jr, Calvani R, et al. Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study. PLoS One 2012; 7: e32829.
    Pubmed KoreaMed CrossRef
  21. Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, et al. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr 2012; 31: 652-8.
    Pubmed CrossRef
  22. Taniguchi M, Fukumoto Y, Kobayashi M, Kawasaki T, Maegawa S, Ibuki S, et al. Quantity and quality of the lower extremity muscles in women with knee osteoarthritis. Ultrasound Med Biol 2015; 41: 2567-74.
    Pubmed CrossRef
  23. Bouchard DR, Janssen I. Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci 2010; 65: 71-7.
    Pubmed CrossRef

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