Korean J Fam Pract. 2018; 8(6): 896-903  https://doi.org/10.21215/kjfp.2018.8.6.896
The Associations between Number of Pregnancy, Age at Childbirth and Dyslipidemia According to Menopause Status in Female Adults with Fertility
Sil-Bi Kang1,2, Mi Ah Han3,*, Jong Park3, So Yeon Ryu3
1Department of Public Health, Graduate School of Health Science, Chosun University; 2Department of Nursing, Kwangju Christian Hospital; 3Department of Preventive Medicine, School of Medicine, Chosun University, Gwangju, Korea
Mi Ah Han
Tel: +82-62-230-6481, Fax: +82-62-225-8293
E-mail: mahan@chosun.ac.kr
ORCID: http://orcid.org/0000-0003-1213-6952
Received: January 15, 2018; Revised: May 23, 2018; Accepted: June 18, 2018; Published online: December 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Reproductive factors such as pregnancy, childbirth, and menopause can have an effect on metabolic diseases in women. The objectives of this study were to investigate the associations between number of pregnancies, age at childbirth, and dyslipidemia according to menopausal status in Korean female adults with fertility.
Methods: The study subjects were 6,194 female adults aged ≥19 years with fertility who participated in the 6th Korea National Health and Nutrition Examination Survey (2013?2015). Hypercholesterolemia, hypertriglyceridemia, decreased high-density lipoprotein (HDL) cholesterolemia, and increased low-density lipoprotein cholesterolemia were assessed using health interviews and examination data. Frequency analysis, chi-square tests, and t-tests were used for statistical analysis. Multiple logistic regression was used to investigate the associations between number of pregnancies, age at childbirth, and dyslipidemia according to menopausal status.
Results: In postmenopausal women, the odds ratio (OR) for hypertriglyceridemia was significantly higher in women who had a first delivery at age <19 years compared to those who delivered at 25?29 years (OR=1.83, 95% confidence interval [Cl]=1.08?3.10). The lower the age at first childbirth, the higher the risk of hypertriglyceridemia (P-trend=0.021). First childbirth at 20?24 years was associated with increased OR for decreased HDL cholesterolemia (OR=1.57, 95% Cl=1.18?2.08) compared to that with first childbirth at 25?29 years.
Conclusion: Age at first childbirth was associated with hypertriglyceridemia and decreased HDL cholesterolemia in postmenopausal women. Further study is needed to identify the biologic mechanisms between age at childbirth and dyslipidemia and the differences in the types of lipids affected.
Keywords: Dyslipidemias; Fertility; Health Surveys; Maternal Age; Menopause; Pregnancy
References
  1. GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1459-544.
    CrossRef
  2. Lim D, Ha M, Song I. Trends in the leading causes of death in Korea, 19832012. J Korean Med Sci 2014; 29: 1597-603.
    Pubmed KoreaMed CrossRef
  3. Miller M. Dyslipidemia and cardiovascular risk: the importance of early prevention. QJM 2009; 102: 657-67.
    Pubmed KoreaMed CrossRef
  4. Korea Centers for Disease Control and Prevention. Korea health statistics 2015: Korea National Health and Nutrition Examination Survey (KNHANES VI-3). Cheongju: Korea Centers for Disease Control and Prevention;2016.
  5. Lee SH. Seomun GA. Investigation of healthy life practices among Korean males and females in relation to dyslipidemia using data from the 2012 Korea National Health and Nutrition Examination Survey. J Digit Converg 2016; 14: 327-38.
    CrossRef
  6. Choi JW, Pai SH. Change in blood lipid levels during normal pregnancy and correlation with alkaline phosphatase cncentrations. J Clin Pathol Qual Control 2000; 22: 225-30.
  7. Han M. Metabolic syndrome emerging from menopause. J Korean Soc Menopause 2011; 17: 127-35.
    CrossRef
  8. Lv H, Yang X, Zhou Y, Wu J, Liu H, Wang Y, et al. Parity and serum lipid levels:a cross-sectional study in chinese female adults. Sci Rep 2016; 6: 33831.
    Pubmed KoreaMed CrossRef
  9. Kritz-Silverstein D, Barrett-Connor E, Wingard DL. The relationship between multiparity and lipoprotein levels in older women. J Clin Epidemiol 1992; 45: 761-7.
    CrossRef
  10. Sim JH, Chung D, Lim JS, Lee MY, Chung CH, Shin JY, et al. Maternal age at first delivery is associated with the risk of metabolic syndrome in postmenopausal women: from 2008-2010 Korean National Health and Nutrition Examination Survey. PLoS One 2015; 10: e0127860.
    Pubmed KoreaMed CrossRef
  11. Park DE, Yoo GS. The delaying & advancing factors of marriage & fertility timing among married women. Korean J Fam Welfare 2011; 16: 29-65
  12. Hwang J, Ryu J, Kim J, Kim S. Individual and familial factors associated with youth sexual experience based on national sample survey. J Korean Data Info Sci Soc 2017; 28: 21-8.
  13. Korea Centers for Disease Control and Prevention. The 11th Korea youth risk behavior web-based survey statistics. Cheongju: Korea Centers for Disease Control and Prevention; 2015.
  14. The Korean Society of Lipid and Atherosclerosis. Korean guidelines for the management of dyslipidemia. 3rd ed. Seoul: The Korean society of Lipid and Atherosclerosis; 2015.
  15. Jang S, Lee J. Prevalence and management of dslipidemia aong Korean aults:KNHANES 2010-2012. J Korea Acad Ind Coop Soc 2015; 16: 7978-89.
  16. Yun YS. Obesity in women: efect of pregnancy and menopause. J Korean Acad Fam Med 2002; 23: 553-64.
  17. We JS, Han K, Kwon HS, Kil K. Effect of maternal age at childbirth on obesity in postmenopausal women: a nationwide population-based study in Korea. Medicine (Baltimore) 2016; 95: e3584.
    Pubmed KoreaMed CrossRef
  18. Sang JH, Park HM, editors. Prevalence of chronic disease in Korean postmenopasal women: National Health and Nutrition Survey 2009. The 97th Korean Society of Obstetrics and Gynecology Conference; 2011 Sep 30Oct 1; Seoul, Korea. Seoul: Korean Society of Obstetrics and Gynecology;2011.
  19. Statistics Korea. Maternal age at childbirth [Internet]. Daejeon: Statistics Korea [cited 2017 Oct 1].
    Available from: http://kosis.kr/statHtml/statHtml.do?orgId=101&tblId=DT_1B81A20&conn_path=I2
  20. Park IH, So CH, Cho JI, Yu ST, Lee SH, Hong KY, et al. Obstetric and neonatal outcomes of teenage pregnancies. J Korean Soc Neonatol 2012; 19: 12733.
    CrossRef
  21. Kim NH, Park YJ, Jung HS. Relationships among sexual knowledge, attitude and sexual behavior that university students perceived. J Psycho Behav 2015; 7: 17-42.
  22. Park S. Age at first childbirth and hypertension in postmenopausal women. Hypertension 2017; 69: 821-6.
    Pubmed CrossRef
  23. Palmer JR, Rosenberg L, Shapiro S. Reproductive factors and risk of myocardial infarction. Am J Epidemiol 1992; 136: 408-16.
    Pubmed CrossRef
  24. Chang HS, Odongua N, Ohrr H, Sull JW, Nam CM. Reproductive risk factors for cardiovascular disease mortality among postmenopausal women in Korea: the Kangwha Cohort Study, 1985-2005. Menopause 2011; 18: 120512.
    Pubmed CrossRef
  25. Kim JH, Jung Y, Kim SY, Bae HY. Impact of age at first childbirth on glucose tolerance status in postmenopausal women: the 2008-2011 Korean National Health and Nutrition Examination Survey. Diabetes Care 2014; 37: 671-7.
    Pubmed CrossRef

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