Korean J Fam Pract 2019; 9(2): 178-184  https://doi.org/10.21215/kjfp.2019.9.2.178
Association of Knee Osteoarthritis with Metabolic Syndrome in Koreans Aged 50-Years or Older
Songhwa Choi1, Min Seob Sim2, Hyoung Gon Song3, Yun-Mi Song1,*
Departments of 1Family Medicine, 2Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 3GemVax & KAEL Co., Ltd, Daejeon, Korea
Yun-Mi Song, Tel: +82-2-3410-2442, Fax: +82-2-3410-0388, E-mail: yunmisong@skku.edu, ORCID: http://orcid.org/0000-0001-9232-5563
Received: July 23, 2018; Revised: October 1, 2018; Accepted: November 2, 2018; Published online: April 20, 2019.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Recent studies have reported the association of knee osteoarthritis (KOA) with metabolic risk factors. The objective of this study was to evaluate the association between KOA and metabolic syndrome (MetS).
Methods: The study subjects were 966 Korean adults aged ≥50 years who participated in a free-of-charge health examination provided to residents of a non-urban area. We ascertained KOA and MetS on the basis of the clinical diagnostic criteria of the American Rheumatism Association and the modified National Cholesterol Education Program’s Adult Treatment Panel III, respectively. The association between KOA and MetS was evaluated using a multiple logistic regression analysis after adjusting for covariates.
Results: The overall prevalence rates of KOA and MetS were 34.9% and 48.7%, respectively, with higher prevalence rates in the women than in the men (P<0.001). The risk of MetS was significantly higher in the subjects with KOA than in those without KOA (odds ratio [OR], 1.35; 95% confidence interval [CI], 1.03–1.77). Among the components of MetS, only abdominal obesity showed a significant association with KOA (OR, 1.48; 95% CI, 1.12–1.95). When the analyses were repeated to determine sex-specific relationships, the associations of KOA with MetS (P=0.069) and abdominal obesity (P=0.022) were evident in the women, but not in the men.
Conclusion: The findings of this study suggest that women with KOA must be evaluated and managed for MetS, with special attention to abdominal obesity.
Keywords: Osteoarthritis, knee; Metabolic Syndrome; Obesity; Korea
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