Korean J Fam Pract 2019; 9(4): 389-393  https://doi.org/10.21215/kjfp.2019.9.4.389
Difference in Mean Platelet Volume between Migraine Patients with and without Aura
Su-Ji Ban1, Jun-Beom Lee2,*, Ga-Heon Jin3, Won-Yong Kim1
Departments of 1Family Medicine and 2Neurology, Hongik Hospital, Seoul; 3Major in Ophthalmic Optics , The Faculty of Beauty Health Sciences, Shinhan University, Uijeongbu, Korea
Jun-Beom Lee
Tel: +82-2-2600-0578, Fax: +82-2-2697-4605
E-mail: acupunct@hanmail.net
ORCID: http://orcid.org/0000-0002-7361-3161
Received: March 5, 2018; Revised: May 25, 2018; Accepted: July 12, 2018; Published online: August 20, 2019.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Mean platelet volume (MPV) increases when platelets are activated, and it is known to increase in migraine patients. The aim of this study is to investigate whether there is a difference in MPV or platelet count between migraine patients with (MA) and without aura (MO).
Methods: Migraine patients were recruited from the out-patient department of a hospital between January 2012 and June 2017. Patients were divided into MA and MO groups. Platelet count and MPV were compared between groups, and the frequency of comorbidities such as ischemic stroke and cardiovascular disease, was investigated in both groups.
Results: Of the 123 patients, 46 were classified as MA, and 77 were classified as MO. The MPV of the MA group was significantly higher than that of the MO group (8.92±0.17 fL, 6.32±0.28 fL, respectively) (P=0.034). However, platelet count showed no significant difference between groups. Cardiovascular disease and ischemic stroke incidences were significantly higher in the MA group than in the MO group (ischemic stroke: 15.2%, 7.8%, respectively, P=0.027; cardiovascular disease: 10.9%, 6.5%, respectively, P=0.018).
Conclusion: Mean platelet volume was significantly greater in the MA group than in the MO group. This may be related to the pathophysiological differences between the two conditions.
Keywords: Mean Platelet Volume; Platelet Activation; Migraine with Aura; Migraine without Aura
References
  1. Tietjen GE, Collins SA. Hypercoagulability and Migraine. Headache 2018; 58: 173-83.
    Pubmed CrossRef
  2. Kim JH. Functional neuroimaging in migraine. Korean J Clin Neurophysiol 2008; 10: 13-24.
  3. Eriksen MK, Thomsen LL, Olesen J. The Visual Aura Rating Scale (VARS) for migraine aura diagnosis. Cephalalgia 2005; 25: 801-10.
    Pubmed CrossRef
  4. Mraovitch S, Calando Y, Goadsby PJ, Seylaz J. Subcortical cerebral blood flow and metabolic changes elicited by cortical spreading depression in rat. Cephalalgia 1992; 12: 137-41; discussion 127.
    Pubmed CrossRef
  5. Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 1981; 9: 344-52.
    Pubmed CrossRef
  6. Lauritzen M, Skyhøj Olsen T, Lassen NA, Paulson OB. Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 1983; 13: 633-41.
    Pubmed CrossRef
  7. Cao Y, Welch KM, Aurora S, Vikingstad EM. Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999; 56: 548-54.
    Pubmed CrossRef
  8. Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 2001; 98: 4687-92.
    Pubmed KoreaMed CrossRef
  9. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 2009; 339: b3914.
    Pubmed KoreaMed CrossRef
  10. Stam AH, Weller CM, Janssens AC, Aulchenko YS, Oostra BA, Frants RR, et al. Migraine is not associated with enhanced atherosclerosis. Cephalalgia 2013; 33: 228-35.
    Pubmed CrossRef
  11. Lechner H, Ott E, Fazekas F, Pilger E. Evidence of enhanced platelet aggregation and platelet sensitivity in migraine patients. Cephalalgia 1985; 5 Suppl 2: 89-91.
    Pubmed CrossRef
  12. Pereg D, Berlin T, Mosseri M. Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction. Platelets 2010; 21: 117-21.
    Pubmed CrossRef
  13. Kishk YT, Trowbridge EA, Martin JF. Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site. Clin Sci (Lond) 1985; 68: 419-25.
    Pubmed CrossRef
  14. Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009; 63: 1509-15.
    Pubmed CrossRef
  15. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-60.
    Pubmed CrossRef
  16. Faraday N, Scharpf RB, Dodd-o JM, Martinez EA, Rosenfeld BA, Dorman T. Leukocytes can enhance platelet-mediated aggregation and thromboxane release via interaction of P-selectin glycoprotein ligand 1 with P-selectin. Anesthesiology 2001; 94: 145-51.
    Pubmed CrossRef
  17. Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol 2011; 31: 1215-8.
    Pubmed CrossRef
  18. Hanington E, Jones RJ, Amess JA, Wachowicz B. Migraine: a platelet disorder. Lancet 1981; 2: 720-3.
    Pubmed CrossRef
  19. Pradalier A, Abuaf N, Launay JM, Vincent D. Platelet size and volume distribution measured by automated platelet analyzer. Cephalalgia 1992; 12: 321-2.
    Pubmed CrossRef
  20. Buttinelli C, Lazzaro MP, Lenzi GL, Paolucci S, Prencipe M. Correlation between migraine and circulating platelet aggregates. Cephalalgia 1985; 5 Suppl 2: 87-8.
    Pubmed CrossRef
  21. Kurabayashi H, Tamura J, Naruse T, Kubota K. Possible existence of platelet activation before the onset of cerebral infarction. Atherosclerosis 2000; 153: 203-7.
    Pubmed CrossRef
  22. Deuel TF, Senior RM, Chang D, Griffin GL, Heinrikson RL, Kaiser ET. Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A 1981; 78: 4584-7.
    Pubmed KoreaMed CrossRef

This Article


Author ORCID Information

Services
Social Network Service

e-submission

Archives