Korean J Fam Pract 2019; 9(6): 532-538  https://doi.org/10.21215/kjfp.2019.9.6.532
Association between Hyperuricemia and Health-Related Quality of Life in Korean Adults: Based on the Seventh Korean National Health and Nutrition Examination Survey (2016–2017)
Zee Hae Bang, Yeon Ji Lee*, Ji-Ho Choi, Yoohyun Kim, Sung Hee An, Min Kyoung Lee, Sangsook Lee
Department of Family Medicine, Inha University College of Medicine, Incheon, Korea
Yeon Ji Lee
Tel: +82-32-890-3547, Fax: +82-32-890-2195
E-mail: dawndusk@naver.com
ORCID: http://orcid.org/0000-0001-7712-996X
Received: October 1, 2019; Accepted: November 4, 2019; Published online: December 20, 2019.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The prevalence of hyperuricemia has increased over the past few decades. Hyperuricemia is responsible for the increased risk of hypertension, type 2 diabetes mellitus, chronic renal disease, and cardiovascular disease. Health-related quality of life (HQoL) has been increasingly used as an outcome in clinical trials, effectiveness research, and research on quality of care. Therefore, we aimed to analyze the association between hyperuricemia and HQoL in Korean adults aged >19 years.
Methods: We included 2,376 male and 2,593 female who participated in the Korea National Health and Nutrition Examination Survey from 2016 to 2017. Hyperuricemia was defined as a serum uric acid (SUA) level of 7 mg/dL. The Euro quality of life-5 dimension (EQ-5D) questionnaire was used to measure HQoL. A multiple logistic regression analysis was performed to examine the association between hyperuricemia and HQoL.
Results: The EQ-5D index score of the hyperuricemia group was significantly lower than of the healthy group. After adjusting for multiple covariates, the odds ratio (95% confidence interval, [CI]) for mobility issues was 1.46 (95% CI, 1.211–1.683) in male and 1.33 (95% CI, 0.716–2.464) in female; however, the difference was not statistically significant for female.
Conclusion: Hyperuricemia was associated with reduced quality of life. It is important to control SUA levels to improve HQoL.
Keywords: Serum Uric Acid; Hyperuricemia; Health-Related Quality of Life; Adults
References
  1. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum 2011; 63: 3136-41.
    Pubmed CrossRef
  2. Qiu L, Cheng XQ, Wu J, Liu JT, Xu T, Ding HT, et al. Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. BMC Public Health 2013; 13: 664.
    Pubmed KoreaMed CrossRef
  3. Kim Y, Kang J, Kim GT. Prevalence of hyperuricemia and its associated factors in the general Korean population: an analysis of a population-based nationally representative sample. Clin Rheumatol 2018; 37: 2529-38.
    Pubmed CrossRef
  4. Kannangara DR, Phipps-Green AJ, Dalbeth N, Stamp LK, Williams KM, Graham GG, et al. Hyperuricaemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urate. Ann Rheum Dis 2016; 75: 1363-6.
    Pubmed CrossRef
  5. Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 1981; 78: 6858-62.
    Pubmed KoreaMed CrossRef
  6. Billiet L, Doaty S, Katz JD, Velasquez MT. Review of hyperuricemia as new marker for metabolic syndrome. ISRN Rheumatol 2014; 2014: 852954.
    Pubmed KoreaMed CrossRef
  7. Nicholls A, Snaith ML, Scott JT. Effect of oestrogen therapy on plasma and urinary levels of uric acid. Br Med J 1973; 1: 449-51.
    Pubmed KoreaMed CrossRef
  8. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. JAMA 2000; 283: 2404-10.
    Pubmed CrossRef
  9. Yamanaka H, Metabolism TG. Essence of the revised guideline for the management of hyperuricemia and gout. Japan Med Assoc J 2012; 55: 324-9.
  10. Nakagawa T, Tuttle KR, Short RA, Johnson RJ. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol 2005; 1: 80-6.
    Pubmed CrossRef
  11. Krishnan E, Baker JF, Furst DE, Schumacher HR. Gout and the risk of acute myocardial infarction. Arthritis Rheum 2006; 54: 2688-96.
    Pubmed CrossRef
  12. Cannon PJ, Stason WB, Demartini FE, Sommers SC, Laragh JH. Hyperuricemia in primary and renal hypertension. N Engl J Med 1966; 275: 457-64.
    Pubmed CrossRef
  13. Schretlen DJ, Inscore AB, Vannorsdall TD, Kraut M, Pearlson GD, Gordon B, et al. Serum uric acid and brain ischemia in normal elderly adults. Neurology 2007; 69: 1418-23.
    Pubmed CrossRef
  14. Roberts JM, Bodnar LM, Lain KY, Hubel CA, Markovic N, Ness RB, et al. Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertension. Hypertension 2005; 46: 1263-9.
    Pubmed CrossRef
  15. Siu YP, Leung KT, Tong MK, Kwan TH. Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level. Am J Kidney Dis 2006; 47: 51-9.
    Pubmed CrossRef
  16. Bhole V, Choi JW, Kim SW, de Vera M, Choi H. Serum uric acid levels and the risk of type 2 diabetes: a prospective study. Am J Med 2010; 123: 957-61.
    Pubmed KoreaMed CrossRef
  17. Lam CL, Lauder IJ. The impact of chronic diseases on the health-related quality of life (HRQOL) of Chinese patients in primary care. Fam Pract 2000; 17: 159-66.
    Pubmed CrossRef
  18. Konstam V, Salem D, Pouleur H, Kostis J, Gorkin L, Shumaker S, et al. Baseline quality of life as a predictor of mortality and hospitalization in 5,025 patients with congestive heart failure. SOLVD Investigations. Studies of Left Ventricular Dysfunction Investigators. Am J Cardiol 1996; 78: 890-5.
    Pubmed CrossRef
  19. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337-43.
    Pubmed CrossRef
  20. Dorman PJ, Waddell F, Slattery J, Dennis M, Sandercock P. Is the EuroQol a valid measure of health-related quality of life after stroke? Stroke 1997; 28: 1876-82.
    Pubmed CrossRef
  21. Schlesinger N, Schumacher HR Jr. Update on gout. Arthritis Rheum 2002; 47:563-5.
    Pubmed CrossRef
  22. Rebollo P, Ortega F, Baltar JM, Díaz-Corte C, Navascués RA, Naves M, et al. Health-related quality of life (HRQOL) in end stage renal disease (ESRD) patients over 65 years. Geriatr Nephrol Urol 1998; 8: 85-94.
    Pubmed CrossRef
  23. Bottomley A, Pe M, Sloan J, Basch E, Bonnetain F, Calvert M, et al.; Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data (SISAQOL) consortium. Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards. Lancet Oncol 2016; 17: e510-4.
    Pubmed CrossRef
  24. Kim JS, Oh MK, Park BK, Lee MK, Kim GJ. Screening criteria of alcoholism by alcohol use disorders identification test(AUDIT) in Korea. J Korean Acad Fam Med 1999; 20: 1152-9.
  25. Lee YK, Nam HS, Chuang LH, Kim KY, Yang HK, Kwon IS, et al. South Korean time trade-off values for EQ-5D health states: modeling with observed values for 101 health states. Value Health 2009; 12: 1187-93.
    Pubmed CrossRef
  26. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1381-95.
    Pubmed CrossRef
  27. Dalbeth N, Petrie KJ, House M, Chong J, Leung W, Chegudi R, et al. Illness perceptions in patients with gout and the relationship with progression of musculoskeletal disability. Arthritis Care Res (Hoboken) 2011; 63: 1605-12.
    Pubmed CrossRef
  28. Roddy E, Zhang W, Doherty M. Is gout associated with reduced quality of life? A case-control study. Rheumatology (Oxford) 2007; 46: 1441-4.
    Pubmed CrossRef
  29. Choi HK, Mount DB, Reginato AM; American College of Physicians, American Physiological Society. Pathogenesis of gout. Ann Intern Med 2005; 143: 499-516.
    Pubmed CrossRef
  30. Chandratre P, Roddy E, Clarson L, Richardson J, Hider SL, Mallen CD. Healthrelated quality of life in gout: a systematic review. Rheumatology (Oxford) 2013;52: 2031-40.
    Pubmed KoreaMed CrossRef

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