General characteristics of the subjects
Variable | Low NFS (N=3,424) |
Intermediate to high NFS (N=280) |
P-value |
---|---|---|---|
Age (y) | 46.3±9.4 | 59.4±10.7 | <0.001 |
Male (%) | 2,475 (72) | 178 (64) | <0.05 |
Waist circumference (cm) | 80.5±5.5 | 79.3±6.9 | <0.05 |
Body mass index (kg/m2) | 23.3±1.7 | 22.6±2.3 | <0.001 |
Body fat mass (kg) | 17.6±4.1 | 16.6±4.6 | <0.001 |
Muscle mass (kg) | 45.8±7.0 | 42.4±7.2 | <0.001 |
Muscle mass deficit (kg) | 2.85±2.11 | 3.79±2.92 | <0.001 |
Systolic blood pressure (mmHg) | 125.3±13.8 | 125.6±17.0 | NS |
Diastolic blood pressure (mmHg) | 77.1±10.3 | 75.4±11.0 | <0.05 |
Heart rate (per min) | 65.9±9.5 | 62.7±9.4 | <0.001 |
AST (IU/L) | 26.1±10.3 | 28.9±18.4 | <0.05 |
ALT (IU/L) | 30.3±18.1 | 20.3±12.2 | <0.001 |
γ-GT (IU/L) | 41.5±57.8 | 56.8±188.4 | NS |
Albumin (g/dL) | 4.5±0.2 | 4.3±0.3 | <0.001 |
Fasting plasma glucose (mg/dL) | 90.5±9.7 | 90.3±10.2 | NS |
HbA1c (%) | 5.4±0.3 | 5.5±0.4 | <0.05 |
eGFR (mL/min/1.73 m2) | 110.6±21.3 | 105.8±21.3 | <0.001 |
Total cholesterol (mg/dL) | 197.8±34.0 | 179.2±35.4 | <0.001 |
Triglyceride (mg/dL) | 144.2±81.9 | 114.6±83.5 | <0.001 |
LDL cholesterol (mg/dL) | 128.5±33.5 | 108.1±33.4 | <0.001 |
HDL cholesterol (mg/dL) | 50.1±11.4 | 53.1±13.3 | <0.001 |
WBC (103/mm3) | 5.94±1.50 | 5.02±1.35 | <0.001 |
Platelet (109/L) | 256.0±53.1 | 172.4±49.4 | <0.001 |
ESR (mm/hr) | 9.38±8.24 | 11.38±9.96 | <0.05 |
hsCRP (mg/dL) | 0.15±0.32 | 0.12±0.28 | NS |
Current smoking (%) | 753 (22) | 29 (10) | <0.001 |
Regular exercise (%) | 1,800 (53) | 168 (60) | <0.05 |
Current medication use (%) | 287 (8) | 31 (11) | NS |
Data are shown as the mean±standard deviation for continuous variables and number (%) for categorical variables.
NFS, nonalcoholic fatty liver disease fibrosis score; HDL, high-density lipoprotein; LDL, low-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; HbA1c, hemoglobin A1c; γ-GT, gamma-glutamyl transferase; WBC, white blood cell; eGFR, estimated glomerular filtration rate; NS, not significant.
aP-value by independent t-test for continuous variables and by Chi-square test for categorical variables.