Summary of recommendations from The American Thoracic Society Clinical Practice Guideline for tobacco-dependent adults with a comorbid psychiatric condition May 202018)
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For tobacco-dependent adults with comorbid psychiatric conditions, including substance-use disorder, depression, anxiety, schizophrenia, and/or bipolar disorder, for whom treatment is being initiated, we recommend varenicline over a nicotine patch (strong recommendation, moderate certainty in the estimated effects). Benefits: Compared with a nicotine patch, varenicline increased eCO-confirmed 7-day point-prevalence abstinence assessed at 6-month follow-up (RR, 1.31; 95% CI, 1.12–1.53) Harms and burdens: Our systematic review suggested that varenicline may decreased the risk of SAEs slightly compared with a nicotine patch (RR, 0.95; 95% CI, 0.54–1.67) |
eCO, exhaled carbon monoxide; RR, risk ratio; CI, confidence interval; SAEs, serious adverse events.
Revised from the article of Leone et al. (Am J Respir Crit Care Med 2020; 202: e5-31).18)