All-cause and cause-specific mortality risk according to weight variability
| VIM | N | Event | Person-years | IR |
Hazard ratio (95% confidence interval) | |||
|---|---|---|---|---|---|---|---|---|
| Model 1 |
Model 2 |
Model 3 |
||||||
| All-cause mortality | Q1 | 441,331 | 2,824 | 4,790,820 | 0.59 | 1 (reference) | 1 (reference) | 1 (reference) |
| Q2 | 444,340 | 2,978 | 4,815,585 | 0.62 | 1.05 (1.00–1.10) | 1.05 (1.00–1.10) | 1.05 (0.99–1.10) | |
| Q3 | 442,636 | 2,933 | 4,779,374 | 0.61 | 1.04 (0.99–1.10) | 1.07 (1.01–1.13) | 1.07 (1.02–1.13) | |
| Q4 | 442,845 | 2,973 | 4,752,808 | 0.63 | 1.07 (1.01–1.12) | 1.19 (1.13–1.25) | 1.20 (1.14–1.26) | |
| Suicide mortality | Q1 | 441,331 | 773 | 4,790,820 | 0.16 | 1 (reference) | 1 (reference) | 1 (reference) |
| Q2 | 444,340 | 854 | 4,815,585 | 0.18 | 1.10 (1.00–1.21) | 1.08 (0.98–1.19) | 1.07 (0.97–1.18) | |
| Q3 | 442,636 | 863 | 4,779,374 | 0.18 | 1.12 (1.02–1.23) | 1.11 (1.01–1.23) | 1.11 (1.01–1.23) | |
| Q4 | 442,845 | 880 | 4,752,808 | 0.19 | 1.15 (1.04–1.27) | 1.23 (1.11–1.35) | 1.26 (1.14–1.39) | |
| Gastrointestinal disease mortality | Q1 | 441,331 | 96 | 4,790,820 | 0.02 | 1 (reference) | 1 (reference) | 1 (reference) |
| Q2 | 444,340 | 88 | 4,815,585 | 0.02 | 0.91 (0.68–1.22) | 0.93 (0.70–1.24) | 0.90 (0.68–1.21) | |
| Q3 | 442,636 | 121 | 4,779,374 | 0.03 | 1.27 (0.97–1.66) | 1.35 (1.03–1.77) | 1.34 (1.02–1.75) | |
| Q4 | 442,845 | 121 | 4,752,808 | 0.03 | 1.29 (0.99–1.69) | 1.58 (1.20–2.07) | 1.61 (1.23–2.11) | |
| Endocrine disease mortality | Q1 | 441,331 | 21 | 4,790,820 | 0.00 | 1 (reference) | 1 (reference) | 1 (reference) |
| Q2 | 444,340 | 16 | 4,815,585 | 0.00 | 0.76 (0.40–1.46) | 0.76 (0.40–1.47) | 0.75 (0.39–1.43) | |
| Q3 | 442,636 | 26 | 4,779,374 | 0.01 | 1.25 (0.70–2.22) | 1.27 (0.71–2.25) | 1.26 (0.71–2.24) | |
| Q4 | 442,845 | 43 | 4,752,808 | 0.01 | 2.10 (1.24–3.53) | 2.11 (1.24–3.56) | 2.16 (1.28–3.65) | |
Values were obtained using multivariable Cox proportional hazards regression analysis.
VIM, variability independent of the mean; IR, incidence rate; Q, quartile.
aIncidence rate per 1,000 person-years.
bModel 1 was unadjusted.
cModel 2 was adjusted for age, sex, income, smoking status, alcohol consumption, physical activity, hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and depression.
dModel 3 was adjusted for age, sex, income, smoking status, alcohol consumption, physical activity, hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, depression, and baseline weight.