Antidepressants for major depressive disorder
| Initial dose (mg/d) |
Dose range (mg/d) |
Adverse effects | |
|---|---|---|---|
| Selective serotonine reuptake inhibitor (SSRI) | |||
| Escitalopram | 10 | 5–20 | Gastrointestinal and sexual side effects, headache, insomnia, anorexia, discontinuation syndrome |
| Fluoxetine | 20 | 20–80 | |
| Paroxetine | 20 | 20–60 | |
| Sertraline | 50 | 50–200 | |
| Fluvoxamine | 50 | 50–300 | |
| Serotonine-norepinephrine reuptake inhibitor (SNRI) | |||
| Desvenlafaxine | 50 | 50–100 | Gastrointestinal and sexual side effects, agitation, insomnia, tremor, hypertension, tachycardia, sweating, discontinuation syndrome |
| Venlafaxine | 75 | 75–225 | |
| Duloxetine | 30 | 30–120 | |
| Noradrenergic and specific serotonergic antidepressant (NaSSA) | |||
| Mirtazapine | 7.5 | 15–45 | Sedation, increased appetite, weight gain |
| Serotonine modulator and stimulator (SMS) | |||
| Vortioxetine | 10 | 10–20 | Gastrointestinal and sexual side effects, dry mouth |
| Norepinephrine-dopamine reuptake inhibitor (NDRI) | |||
| Bupropion | 150 | 150–450 | Tachycardia, agitation, insomnia, seizures, dry mouth |
| Melatonergic agonist and serotonine-2c antagonist | |||
| Agomelatine | 25 | 25–50 | Headache, gastrointestinal side effects, fatigue, abnormal dream, abnormal liver function test |