Korean J Fam Pract 2013; 3(3): 308-314  
The Relationship between the Increase of White Blood Cell and Development of Hyperglycemia among Healthy Adult Males
Seung-Hwa Lee, Seon Mee Kim1,*
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon; 1Department of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
Published online: September 30, 2013.
© The Korean Academy of Family Medicine. All rights reserved.

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Abstract
Background: Until recently, several studies have shown development of diabetes mellitus to be related to chronic infl ammation with proven evidence that increase of several infl ammatory markers have been reported. The authors of this investigation studied the relationship between white blood cell (WBC) count and hyperglycemia as well as the value of predicting factor with the introduction of cut-off value.
Methods: During this study, among 3,277 males, we targeted 2,953 males who did not have diseases during an employee health examination in which there were no missing values. The targeted data was taken from WBC count of 1999 year employee health examination which was then divided into fi ve groups. These fi ve groups were compared to 2003 year data to calculate the development of a hyperglycemia odds ratio. Also, cut-off value of WBC count was calculated by using receiver operating characteristic (ROC)-curve.
Results: The level of WBC increase in regard to hyperglycemia correlated with an odds ratio of 1.10 (95% confi dence interval [CI], 0.90 to 1.31), 1.19 (95% CI, 1.00 to 1.39), 1.37 (95% CI, 1.15 to 1.54), 1.45 (95% CI, 1.25 to 1.66), respectively in which the cut-off value of WBC count was 8,327 cells/ՌL (sensitivity 70.5%, specifi city 60.2%). The area under curve of ROC-curve was 0.72 (95% CI, 0.70 to 0.74).
Conclusion: Our fi ndings demonstrated that an increase in the amount of white blood cell even in a normal range can have a correlation with the risk of hyperglycemia. This also proved to be valid yet with the correction of other risk factors. Therefore, WBC level can not only be utilized for common diseases but also be associated with hyperglycemia and can be predicting factor.
Keywords: Leukocyte Count; Diabetes Mellitus; Prediabetic State; Hyperglycemia; Insulin Resistance

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