Korean J Fam Pract. 2018; 8(5): 684-689  https://doi.org/10.21215/kjfp.2018.8.5.684
The Relation of High-Sensitivity C-Reactive Protein with Metabolic Syndrome in Korean Adults: Based on the Korean Health and Nutrition Examination Survey, 2015
Sung Kyum Kim, Jin A Park*, Sang Keun Ham, Min Woo Shin, Eun Hye Yu, Yong Ho Sohn
Department of Family Medicine, Hanil General Hospital, Seoul, Korea
Jin A Park
Tel: +82-2-901-3114, Fax: +82-2-901-3174
E-mail: 03680528@hanilmed.net
ORCID: http://orcid.org/0000-0001-6982-9309
Received: July 21, 2017; Revised: October 24, 2017; Accepted: October 26, 2017; Published online: October 20, 2018.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Metabolic syndrome is a group of multiple metabolic disorders that increase the risk of cardiovascular diseases and type 2 diabetes. C-reactive protein (CRP) level is a marker of systemic inflammation, and its correlation with coronary arterial disease has recently been highlighted. The purpose of this study was to determine the relationship between metabolic syndrome and CRP level, as well as between each metabolic syndrome component and CRP level.
Methods: On the basis of the data from the Sixth Korea National Health and Nutrition Examination Survey conducted in 2015, 3,705 people were selected. They were grouped according to general and lifestyle characteristics such as age, sex, alcohol drinking, and smoking status. The correlation of high-sensitivity (hs-CRP) level according to these variables was analyzed statistically. The correlation between each component of the metabolic syndrome and hs-CRP level was examined using one-way analysis of variance. Finally, the association of hs-CRP level with metabolic syndrome was examined using logistic regression analysis.
Results: hs-CRP level correlated with male sex, age, high-risk drinking, and smoking status. Overall, high hs-CRP level correlated with the high incidence rate of metabolic syndrome. The metabolic syndrome components such as waist circumference, triglyceride level, high-density lipoprotein cholesterol level, blood pressure, and blood glucose level showed statistically significant correlations with hs-CRP level.
Conclusion: Each metabolic syndrome component showed a significant difference according to hs-CRP level. The group with metabolic syndrome had a high hs-CRP level as a whole. This study showed that high hs-CRP levels were also associated with the prevalence of metabolic syndrome.
Keywords: Korea National Health and Nutrition Examination Survey; Metabolic Syndrome; High-Sensitivity C-Reactive Protein; Korean Adult
References
  1. The Statistics Korea. Cause of death statistics in 2015. Daejeon: Statistics Korea; 2015.
  2. Isomaa B, Almgren P, Tuomi T, Forsén B, Lahti K, Nissén M, et al. Cardiovascular morbidity and mortality associated with the metalobic syndrome. Diabetes Care 2001; 24; 683-9.
    Pubmed CrossRef
  3. Lakka H, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2001; 288: 2709-16.
    CrossRef
  4. Lim S, Shin H, Song JH, Kwak SH, Kang SM, Won Yoon J, et al. Increasing prevalence of metabolic syndrome in Korea: the Korean national health and nutrition examination survey for 1998-2007. Diabetes Care 2011; 34: 13238.
    Pubmed KoreaMed CrossRef
  5. Haverkate F, Thompson SG, Pyke SD, Gallimore JR, Pepys MB. Production of C-reactive protein and risk of coronary eventsin stable and unstable angina:European concerted action on thrombosis and disabilities angina pectoris study group. Lancet 1997; 349: 462-6.
    CrossRef
  6. Koenig W, Sund M, Fröhlich M, Fischer HG, Löwel H, Döring A, et al. CReactiveprotein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (monitoring trends and determinants in cardiovascular disease) Augsburg Cohort study, 1984 to 1992. Circulation 1999; 99: 237-42.
    Pubmed CrossRef
  7. Rohde LE, Hennekens CH, Ridker PM. Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men. Am J Cardiol 1999;84: 1018-22.
    CrossRef
  8. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 2003; 107: 391-7.
    Pubmed CrossRef
  9. Ridker PM. High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001; 103: 1813-8.
    Pubmed CrossRef
  10. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-421.
    Pubmed CrossRef
  11. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007; 75: 72-80.
    Pubmed CrossRef
  12. Sattar N, Gaw A, Scherbakova O, Ford I, O’Reilly DS, Haffner SM, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland coronary prevention study. Circulation 2003; 108: 414-9.
    Pubmed CrossRef
  13. Rutter MK, Meigs JB, Sullivan LM, D’Agostino RB Sr, Wilson PW. C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring study. Circulation 2004; 110: 380-5.
    Pubmed CrossRef
  14. Mirhafez SR, Ebrahimi M, Saberi Karimian M, Avan A, Tayefi M, HeidariBakavoli A, et al. Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects. Eur J Clin Nutr 2016; 70: 1298-304.
    Pubmed CrossRef
  15. Kazemi-Bajestani SM, Tayefi M, Ebrahimi M, Heidari-Bakavoli AR, Moohebati M, Parizadeh SM, et al. The prevalence of metabolic syndrome increases with serum high sensitivity C-reactive protein concentration in individuals without a history of cardiovascular disease: a report from a large Persian cohort. Ann Clin Biochem 2017; 54: 644-8.
    CrossRef
  16. Bustos P, Rosas B, Román P, Villagrán J, Amigo H. [Association of C reactive protein levels with metabolic syndrome in adults: a population-based study]. Rev Med Chil 2016; 144: 1239-46. Spanish.
    Pubmed CrossRef
  17. Vidyasagar S, UK Razak A, Prashanth CK, Varma DM, Bairy KL. Highly sensitive C-reactive protein in metabolic syndrome. JIACM 2013; 14: 230-4
  18. Kim YJ, Hwang SB, Kim SY, Hwang IH. The association between C-reactive protein and features of the metabolic syndrome. Korean J Fam Med 2003;24: 456-60.
  19. Jung SB, Song YA, Chung DH, Choi BG, Oh JE, Cho CY, et al. The association between metabolic syndrome and high-sensitivity C-reactive protein. Korean J Fam Pract 2016; 6: 367-70.
    CrossRef
  20. Park JS, Kim YJ, Lee JG, Kim YJ, Lee SY, Min HG. The role of C-reactive proteinas a inflammation-related factor in metabolic syndrome. Korean J Fam Med 2009; 30: 449-56.
    CrossRef


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