Korean J Fam Pract 2019; 9(2): 173-177  https://doi.org/10.21215/kjfp.2019.9.2.173
Association between Physical Activity and Estimated Glomerular Filtration Rate in Adults
Eunshik Mo, Min-Jeong Kim*, Seok-joong Kim, Hyung-joo Kim, Byung-hyun Chae, Sujeong Kang, Jaeyoung Park
Department of Family Medicine, National Medical Center, Seoul, Korea
Min-Jeong Kim, Tel: +82-2-2260-4717, Fax: +82-2-2262-4739, E-mail: seiten@hanmail.net, ORCID: http://orcid.org/0000-0002-6680-4699
Received: July 23, 2018; Revised: August 27, 2018; Accepted: September 12, 2018; Published online: April 20, 2019.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: This study was conducted to examine the correlation between physical activity and estimated glomerular filtration rate (eGFR) in Korean adults.
Methods: We selected 6,546 adults aged >19 years from among the participants of the 2016 National Health and Nutrition Survey. Physical activity and sedentary time were measured using the global physical activity questionnaires developed by the World Health Organization. eGFR was calculated using the Modification of Diet in Renal Disease equation. After adjustment for covariates (age, marital status, hypertension, diabetes, myocardial infarction, drinking, smoking, total cholesterol level, body mass index, and C-reactive protein level), the correlations among physical activity, sedentary time, and eGFR were analyzed using multivariate linear regression analysis.
Results: No correlation was found between physical activity level and eGFR. However, sedentary time was significantly correlated with eGFR. The result showed that eGFR increased as sedentary time decreased.
Conclusion: No correlation was found between physical activity level and eGFR in adults aged >19 years, but sedentary time was significantly correlated with eGFR. Further research is needed to clarify the relationship between physical activity and eGFR, using other physical activity indicators and changing the physical activity criteria.
Keywords: Physical Activity; Sedentary Time; Kidney Function; Estimated Glomerular Filtration Rate
  1. Locatelli F, Vecchio LD, Pozzoni P. The importance of early detection of chronic kidney disease. Nephrol Dial Transplant 2002; 17 Suppl 11: 2-7.
    Pubmed CrossRef
  2. Barsoum RS. Chronic kidney disease in the developing world. N Engl J Med 2006; 354: 997-9.
    Pubmed CrossRef
  3. Kim S, Lim CS, Han DC, Kim GS, Chin HJ, Kim SJ, et al. The prevalence of chronic kidney disease (CKD) and the associated factors to CKD in urban Korea: a population-based cross-sectional epidemiologic study. J Korean Med Sci 2009; 24 Suppl: S11-21.
    Pubmed KoreaMed CrossRef
  4. Lim K, Taylor L. Factors associated with physical activity among older people: a population-based study. Prev Med 2005; 40: 33-40.
    Pubmed CrossRef
  5. Siscovick DS, Fried L, Mittelmark M, Rutan G, Bild D, O'Leary DH. Exercise intensity and subclinical cardiovascular disease in the elderly. The Cardiovascular Health Study. Am J Epidemiol 1997; 145: 977-86.
    Pubmed CrossRef
  6. DiPietro L. Physical activity in aging: changes in patterns and their relationship to health and function. J Gerontol A Biol Sci Med Sci 2001; 56: 13-22.
    Pubmed CrossRef
  7. Guo VY, Brage S, Ekelund U, Griffin SJ, Simmons RK; ADDITION-Plus study team. Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed type 2 diabetes: a prospective cohort analysis. Diabet Med 2016; 33: 1222-9.
    Pubmed KoreaMed CrossRef
  8. Bharakhada N, Yates T, Davies MJ, Wilmot EG, Edwardson C, Henson J, et al. Association of sitting time and physical activity with CKD: a cross-sectional study in family practices. Am J Kidney Dis 2012; 60: 583-90.
    Pubmed CrossRef
  9. Parsons TJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, Lee IM, et al. Objectively measured physical activity and kidney function in older men; a cross-sectional population-based study. Age Ageing 2017; 46: 1010-4.
    Pubmed KoreaMed CrossRef
  10. Foster MC, Hwang SJ, Massaro JM, Jacques PF, Fox CS, Chu AY. Lifestyle factors and indices of kidney function in the Framingham heart study. Am J Nephrol 2015; 41: 267-74.
    Pubmed KoreaMed CrossRef
  11. White SL, Dunstan DW, Polkinghorne KR, Atkins RC, Cass A, Chadban SJ. Physical inactivity and chronic kidney disease in Australian adults: the AusDiab study. Nutr Metab Cardiovasc Dis 2011; 21: 104-12.
    Pubmed CrossRef
  12. World Health Organization. Global recommendations on physical activity for health [Internet]. Geneva: World Health Organization; 2010 [cited 2016 Nov 26].
  13. World Health Organization. Global physical activity surveillance [Internet]. Geneva: World Health Organization; 2010 [cited 2016 Nov 26].
  14. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461-70.
    Pubmed CrossRef
  15. Silva FG. The aging kidney: a review -- part I. Int Urol Nephrol 2005; 37:185-205.
    Pubmed CrossRef
  16. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al.;Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56:M146-56.
    Pubmed CrossRef
  17. Fedorowski A, Hedblad B, Engström G, Gustav Smith J, Melander O. Orthostatic hypotension and long-term incidence of atrial fibrillation: the Malmö preventive project. J Intern Med 2010; 268: 383-9.
    Pubmed CrossRef

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