Korean J Fam Pract 2020; 10(2): 143-148  https://doi.org/10.21215/kjfp.2020.10.2.143
The Associations between Dietary Intake of N-3 Fatty Acids and 10-Year Cardiovascular Disease Risk: The Korea National Health and Nutrition Examination Survey, 2012–2016
Sujeong Kang, Min-jeong Kim*, Seok-joong Kim, Jaeyoung Park, Ju Youn An, Mina Choi
Department of Family Medicine, National Medical Center, Seoul, Korea
Min-jeong Kim
Tel: +82-2-2260-4717, Fax: +82-2-2262-4739
E-mail: seiten@hanmail.net
ORCID: http://orcid.org/0000-0002-6680-4699
Received: August 10, 2019; Revised: February 27, 2020; Accepted: March 11, 2020; Published online: April 20, 2020.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Dietary intake of n-3 fatty acids have been suggested for their protective role against cardiovascular disease. However, findings from recent studies have been inconsistent. Thus, we investigated the association between dietary intake of n-3 fatty acids and the 10-year risk of cardiovascular disease (CVD).
Methods: We analyzed data from 17,390 adults who were aged 30–64 years and free of CVD using the Korea National Health and Nutrition Examination Survey, 2012–2016. Dietary intake of n-3 fatty acids was calculated by using food-frequency questionnaire, and the 10 year risk of CVD was calculated by Framingham general cardiovascular disease risk score (2008) model. We analyzed the odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression to evaluate the association between dietary intake of n-3 fatty acids and the 10-year risk of CVD.
Results: Logistic regression anlaysis showed that dietary intake of n-3 fatty acids was not significantly associated with the 10-year risk of CVD, after adjusting for confounders (OR=0.91; 95% CI, 0.77–1.07). But higher dietary intake of n-3 fatty acids was associated with reduced the 10-year risk of CVD for the female (OR=0.74; 95% CI, 0.58–0.95).
Conclusion: Our research indicated no significant association between dietary intake of n-3 fatty acids and the 10-year risk of CVD. But the inverse association was observed in the female.
Keywords: Fatty Acids, Omega-3; Cardiovascular Disease; Risk Assessment; Primary Prevention
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