Korean J Fam Pract 2020; 10(4): 256-261  https://doi.org/10.21215/kjfp.2020.10.4.256
How Well Can Matrix of Ferritin and Neutrophil to Lymphocyte Ratio Predict Metabolic Syndrome in Korean Adults?
Jin Gu Kim, Mi Ji Lee, Young Hye Kim, Kyunam Kim*, Seon Yeong Lee, Jong Woo Kim, Jeong Ki Paek
Department of Family Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Kyunam Kim
Tel: +82-2-950-1150, Fax: +82-2-950-4093
E-mail: kimkn@paik.ac.kr
ORCID: http://orcid.org/0000-0003-4168-4616
Received: August 10, 2019; Revised: April 23, 2020; Accepted: May 20, 2020; Published online: August 20, 2020.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Previous studies have shown that elevated ferritin level and neutrophil to lymphocyte ratio (NLR) are risk factors of chronic low-grade inflammation and contribute to the onset and progression of cardiovascular disease. In addition, metabolic syndrome has a similar relevance; thus, in this study, we aimed to determine how well metabolic syndrome could be predicted by measuring ferritin level and NLR.
Methods: From January 2016 to September 2018, 1,815 adults who underwent medical interviews, physical measurements, and blood tests at a medical examination center of a university hospital in Seoul were evaluated. Data were analyzed using the Spearman correlation analysis, an average comparison using analysis of variance, and a t test. The prevalence of metabolic syndrome was determined according to ferritin level and NLR.
Results: We found a significant correlation between the components of metabolic syndrome and ferritin level, but not NLR. The NLRs were divided into quartiles for comparison with the mean values of the components of metabolic syndrome, but the results were not significant. A significant difference was found only in ferritin level when we compared the mean values of ferritin level and NLR according to the presence or absence of a metabolic syndrome diagnosis. When ferritin level and NLR were considered simultaneously, the prevalence of metabolic syndrome tended to change only when the ferritin level changed.
Conclusion: In healthy Korean adults, ferritin level, but not NLR, could be used as a predictor of metabolic syndrome.
Keywords: Serum Ferritin; Neutrophil to Lymphocyte Ratio; Metabolic Syndrome; Cardiovascular Disease
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