Korean J Fam Pract 2020; 10(5): 393-397  https://doi.org/10.21215/kjfp.2020.10.5.393
Predictors of Serum Low-Density Lipoprotein Cholesterol Level in Postmenopausal Women
Dong Jung, Hee Jeong Choi*, Ye Na Shim, Min So Jo, Han Jin Oh
Department of Family Medicine, Eulji University Hospital, Daejeon, Korea
Hee Jeong Choi
Tel: +82-42-611-3231, Fax: +82-42-611-3776
E-mail: ohinia@daum.net
ORCID: https://orcid.org/0000-0001-6085-5770
Received: September 7, 2020; Revised: September 22, 2020; Accepted: September 23, 2020; Published online: October 20, 2020.
© The Korean Academy of Family Medicine. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In general, women tend to increase serum low-density lipoprotein cholesterol levels after menopause. Hypercholesterolemia is a risk factor that causes atherosclerosis and increases the risk of cardiovascular disease. Additionally, low-density lipoprotein cholesterol increases even when attempting to modify lifestyles in menopausal women. Therefore, we wanted to find out what risk factors are associated with low-density lipoprotein cholesterol in menopausal women.
Methods: Data were gathered from 4,943 subjects who had visited a Health Promotion Center. Variables are measured in body metering and blood tests. Partial correlation analysis was performed to identify the variables that are related to low-density lipoprotein cholesterol, and multiple regression analysis was performed to find the variables that can predict low-density lipoprotein cholesterol.
Results: The mean age of the subjects was 57.3±6.6 years old, the average low density lipoprotein cholesterol concentration was 124.6±33.3 mg/dL, the average body mass index was 23.6±3.2 kg/m2, and the average waist circumference was 78.4±8.3 cm, and 21.5 percent of subjects was abdominal obesity. Serum low-density lipoprotein cholesterol level showed a positive correlation with obesity, oxidative stress-related indices, and inflammatory markers such as ESR, CRP. ESR, body fat mass, total bilirubin, uric acid, fasting plasma glucose, and WBC count showed positive correlation with serum low-density lipoprotein cholesterol levels, and age showed negative correlation.
Conclusion: This study identified several factors, such as inflammatory markers, obesity and oxidative stress related indices were associated with elevated serum low-density lipoprotein cholesterol levels in postmenopausal women.
Keywords: Menopause; Cholesterol, LDL; Dyslipidemias; Risk Factors
References
  1. Phan BA, Toth PP. Dyslipidemia in women: etiology and management. Int J Womens Health 2014; 6: 185-94.
    Pubmed KoreaMed CrossRef
  2. Schnatz PF, Schnatz JD. Dyslipidemia in menopause: mechanisms and management. Obstet Gynecol Surv 2006; 61: 608-13.
    Pubmed CrossRef
  3. Barton M, Meyer MR, Haas E. Hormone replacement therapy and atherosclerosis in postmenopausal women: does aging limit therapeutic benefits? Arterioscler Thromb Vasc Biol 2007; 27: 1669-72.
    Pubmed CrossRef
  4. Kim CJ, Kim TH, Ryu WS, Ryoo UH. Influence of menopause on high density lipoprotein-cholesterol and lipids. J Korean Med Sci 2000; 15: 380-6.
    Pubmed KoreaMed CrossRef
  5. Koba S, Hirano T. [Dyslipidemia and atherosclerosis]. Nihon Rinsho 2011;69: 138-43. Japanese.
  6. Yeasmin N, Akhter Q, Mahmuda S, Nahar S, Rabbani R, Hasan M, et al. Effect of estrogen on serum total cholesterol and triglyceride levels in postmenopausal women. J Dhaka Med Coll 2017; 26: 25-31.
    CrossRef
  7. Rhee EJ, Kim HC, Kim JH, Lee EY, Kim BJ, Kim EM, et al. 2018 Guidelines for the management of dyslipidemia in Korea. Korean J Intern Med 2019;34: 1171.
    Pubmed KoreaMed CrossRef
  8. Ko SH, Kim HS. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients 2020; 12: 202.
    Pubmed KoreaMed CrossRef
  9. Kim CJ. Effect of management of dyslipidemia on prevention of coronary artery disease in women. Korean Circ J 2000; 30: 1055-60.
    CrossRef
  10. Kim CJ, Jang HC, Cho DH, Min YK. Effects of hormone replacement therapy on lipoprotein(a) and lipids in postmenopausal women. Arterioscler Thromb 1994; 14: 275-81.
    Pubmed CrossRef
  11. Thaung Zaw JJ, Howe PRC, Wong RHX. Postmenopausal health interventions:time to move on from the Women's Health Initiative? Ageing Res Rev 2018; 48: 79-86.
    Pubmed CrossRef
  12. Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2017; 38: 2459-72.
    Pubmed KoreaMed CrossRef
  13. Korean Society of Lipid and Atherosclerosis. Dyslipidemia fact sheets in Korea, 2018. Seoul: Korean Society of Lipid and Atherosclerosis; 2018.
    Pubmed KoreaMed CrossRef
  14. Haffner SM, Valdez RA. Endogenous sex hormones: impact on lipids, lipoproteins, and insulin. Am J Med 1995; 98: 40S-7S.
    CrossRef
  15. Zhang Y, Li S, Xu RX, Zhu CG, Guo YL, Wu NQ, et al. Systemic inflammatory markers are closely associated with atherogenic lipoprotein subfractions in patients undergoing coronary angiography. Mediators Inflamm 2015;2015: 235742.
    Pubmed KoreaMed CrossRef
  16. Fessler MB, Rose K, Zhang Y, Jaramillo R, Zeldin DC. Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population. J Lipid Res 2013; 54: 3177-88.
    Pubmed KoreaMed CrossRef
  17. Oda E. LDL cholesterol was more strongly associated with percent body fat than body mass index and waist circumference in a health screening population. Obes Res Clin Pract 2018; 12: 195-203.
    Pubmed CrossRef
  18. Choi SH, Yun KE, Choi HJ. Relationships between serum total bilirubin levels and metabolic syndrome in Korean adults. Nutr Metab Cardiovasc Dis 2013; 23: 31-7.
    Pubmed CrossRef
  19. Boon AC, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner KH, et al. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic Biol Med 2012;52: 2120-7.
    Pubmed KoreaMed CrossRef
  20. Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids 2008; 27: 608-19.
    Pubmed KoreaMed CrossRef
  21. Cho GJ, Lee JH, Park HT, Shin JH, Hong SC, Kim T, et al. Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome. Menopause 2008; 15: 524-9.
    Pubmed CrossRef
  22. Matthews KA, Crawford SL, Chae CU, Everson-Rose SA, Sowers MF, Sternfeld B, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol 2009; 54: 2366-73.
    Pubmed KoreaMed CrossRef
  23. Lee YH, Lee SG, Lee MH, Kim JH, Lee BW, Kang ES, et al. Serum cholesterol concentration and prevalence, awareness, treatment, and control of high low-density lipoprotein cholesterol in the Korea National Health and Nutrition Examination Surveys 2008-2010: beyond the tip of the iceberg. J Am Heart Assoc 2014; 3: e000650.
    CrossRef

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